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《CHINESE JOURNAL OF HEMATOLOGY》 2000-07
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The St14(DXS 52)VNTR in a Guangdong Han population and detection of hemophilia A carriers

MA Aihua, ZENG RuiPing, HE Qicai. Department of Medical Genetics, Sun Yat sen University of Medical Sciences, Guangzhou 510089, China  
Objective To investigate the genetic polymorphism of the St14(DXS 52) variable number tandem repeat (VNTR) in normal individuals in Guangdong, and to evaluate the efficacy of this marker for the gene diagnosis of hemophilia A. Methods 125 unrelated healthy individuals (male 21, female 104) and 4 hemophilia A families were detected using amplified fragment length polymorphism (Amp FLP). Results 11 allelic fragments ranging from 700 to 1?810?bp in size and 7 different genotypes in males,17 different genotypes in females were observed, respectively. The allele frequencies were 0.004?4 to 0.480?3. The polymorphism information contents (PIC) was 0.733?5, and the heterozygosity was 0.432. Four families with hemophilia A were analyzed and 2 of them were informative for linkage analysis. In one family, 2 females were determined to be normal individuals, not carriers, one female carrier was detected in the other family. Conclusion St14(DXS 52) was a useful polymorphism marker for carrier detection of hemophilia A in southern Chinese population, and it was different from those in Caucasian.
【Fund】: 美国中华医学基金会(CMB)资助
【CateGory Index】: R554.1
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【References】
Chinese Journal Full-text Database 2 Hits
1 ZHONG Chang-gao, LI Lu-yun, LU Guang-xiu.(Institute of Reproductive and Stem Cell Engineering, Central South University, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha,Hunan, 410078 P.R.China.);Diagnosis of hemophilia A by a combination of St14(DXS52) VNTR polymorphism and (CA)n repeat polymorphism within FⅧ gene[J];Chinese Journal of Medical Genetics;2004-01
2 FENG Da-wei,YANG Lin-hua,GUO Zhi-ping.Department of Hematology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Detection and analysis of polymorphism of ST14 site in hemophilia A patients and their family[J];Chinese Remedies & Clinics;2011-07
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Guang Wei, Wang Jin, Du Chuanshu, et al. Department of Medical Genetics, Sun Yat sen University of Medical Sciences. Guangzhou 510089;A CASE OF p16 GENE DELETION IN WILM'S TUMOR[J];CHINESE JOURNAL OF MEDICAL CENETICS;1997-01
2 Jin Chunlian *, Lin Changkun, Song Jun, Jiang Li, Dong Wenhan, Zhang Xue, Sun Kailai.*Department of Medical Genetics, China Medical University, Shenyang, 110001;POLYMORPHISM DISTRIBUTION OF ST14(DXS52) VNTR IN NORMAL INDIVIDUALS IN NORTHEASTERN REGION OF CHINA AND ITS APPLICATION IN GENE DIAGNOSIS OF HEMOPHILIA A[J];CHINESE JOURNAL OF MEDICAL GENETICS;1998-01
3 Luo Chaoquan Wu Xinyao Yang Yinghao Du Huawei He Qicai Liu Xiwen (1. Department of Biochemistry 2. Department of Forensic Biology 3. Department of Physics);DNA RFLPS DETECTED BY pAW101 PROBE IN THE POPULATION OF GUANGDONG; CHINA[J];;1992-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Li ye, WANG Hui zhong, HUANG Ge, GAO Hong (General Hospital of Chaozhou, Chaozhou, 521021, China);p16 GENE EXPRESSION IN WILMS TUMORS AND ITS RELATIONSHIP WITH PATHOLOGICAL TYPE AND CLINICAL STAGE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-02
2 Liu Chao ;Luo Chaoquan ;Yang Yinghao;Wu Xinyao;Luo Jianyang(Sun yatsen University of Medical Sciences (Guangzhou 510089));RFLPs ANALYSIS OF DIGOXIGENIN-LABELLED pAW101 PROBE AND ITS PRACTICAL USES[J];Chinese Journal of Forensic Medicine;1994-03
3 KONG Xiangdong, SHI Huirong, WEI Zhenling, ZHANG Yingying, WANG Huiling Department of Gynecology and Obstetrics, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;Prenatal diagnosis in eleven families with hemophilia A of inversion negative in intron 22 of factor Ⅷ gene[J];Journal of Zhengzhou University(Medical Sciences);2008-01
4 WANG Xue-feng;Experimental Text and Clinical Application on Hemorrhage Disease[J];Continuing Medical Education;2006-26
5 Du Ai-min, Wu Guo-xiang, Fu Wei-jun (The PLA 85th Hospital);The Vacant Status of p16 in Primary Tumors of Digestive Tract[J];Chinese Journal of Clinical Gastroenterology;2000-02
6 Du Ai min, Wu Guo xiang 85th Hospital of PLA, Shanghai 200052;The Vacant Status of p16 Gene in Primary Hepatocarcinoma[J];Chinese Journal of Clinical Gastroenterology;2001-03
7 Yang Liye, Wang Huizhong, Gao Hong (The Key Laboratory of Congenital Malformation,The Second Hospital Affiliated to China Medical University,Liaonin Shenyang,110003);p16 Gene Expression in Wilms Tumors[J];ACTA ACADEMIAE MEDICINAE SUZHOU;2000-10
8 WU Chaoyang, LIU Mugeng, SHEN Ruilan, et al. Department of Hematology,The First Affiliated Hospital,Nanjing Medical University,Nanjing 210029;Study on the polymorphism of microsatellite repeat within FⅧ gene in chinese Han[J];Jiangsu Medical Journal;2001-04
9 He Qicai Tan Runchu Wu Xinyao Luo Chaoquan Yang Yinghao ( Department ofPhysics , Sun Yat-Sen University of Medical Sciences, Department of biochemistry ,Cuang≈hou , 51 0089 );THE TESTING METHOD OF HAPDY-WEINBERG'S EQUILIBRIUMCOINCIDENCE DEGREE BY COMPUTER PROGRAM[J];CHINESE JOURNAL OF MEDICAL PHYSICS;1997-02
10 Lin Changkun, Jin Chunlian, Wang Min, Sun Kailai (Department of Medical Genetics, College of Basic Medical Sciences, China Medical University, Shenyang, 110001);Distribution of Intron 13 (CA)n Polymorphism of Factor Ⅷ Gene in Healthy Han People in Northeast of China[J];Journal of China Medical University;2001-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LU Yeling,DING Qiulan,DAI Jin,et al.Department of Transfusion,Ruijin Hospital,Shanghai 200025,China;Carrier detection and prenatal diagnosis of haemophilia[J];Chinese Journal of Blood Transfusion;2008-04
2 LUOChen 1 ,XINGFu-qi 1 ,LUOShen-qiu 2 Centerof AssistedReproduction,NanfangHospital 1 ,Departmentof CellularBiologyandMedicalGenetics 2 ,First MilitaryMedicalUniversity,Guangzhou510515,China;Normal pregnancy in a woman having had a child with trisomy 21syndrome before:application of preimplantation genetic diagnosis[J];Journal of First Military Medical University;2002-03
3 YANG Linhua GUO Yanli GUO Zhiping HOU Lihong LIU Xiue (Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan, 030001, China);Analyze haemophilia a family by using inherited polymovphism linkage analysis[J];Journal of Clinical Hematology;2005-03
4 Wang Xiaodong (Jiangsu Institute of Hemotology,Suzhou Medical College);St14(DXS 52)Vntr in Chin ese Population and its Application to Gene Diagnosis of hemophilia A[J];Acta Academiae Medicinae Suzhou;1996-01
5 Tao Ye *,Jin Fan,Huang Hefeng,et al. * The First People's Hospital of Yuhang City,Yuhang,Zhejiang,311100,China;Single cell analysis of DMD and SRY gene by 5-plex nest PCR[J];Chinese Journal of Practical Gynecology and Obstetrics;2001-08
6 JIAO Ze xu,ZHUANG Guang lun,ZHOU Can quan,SHU Yi min,LI Je,LIANG Xiao yan,ZHANG Min fang,DENG Ming fen. Reproductive Medical Center,Department of Obstetrics and Gynecology,First Affiliated Hospital of Sun Yet Sen University,Guangzhou 510080,China;Successful preimplantation genetic diagnosis for beta-thalassemia using primer extension preamplification[J];Chinese Journal of Obstetrics and Gynecology;2003-03
7 FU Junjiang, LI Luyun, LU Guangxiu Laboratory of Human Reproductive Engineering, Central South University Xiangya Medical College, Changsha 410078, China;Prenatal gene diagnosis of spinal muscular atrophy by combined with the technique of PCR-SSCP, PCR followed by restriction enzyme digestion and linkage analysis[J];Chinese Journal of Neurology;2001-02
8 Liu Jianxiang; Zhang Yuzhou;Wang Hongli;et al.(Shanghai Institute of Hematology,Rui jin Hospital,Shanghai Second Medi cal University,Shanghai 200025);Molecular characterization of genetic defects in hemophilia in Shanghai[J];CHINESE JOURNAL OF HEMATOLOGY;1997-09
9 WANG Xuefeng,LIU Yuanfang,LI Zhiguang, et al. Shanghai Institute of Hematology,Ruijin Hospital, Shanghai Second Medical University,Shanghai 200025,China;Carrier detection and prenatal diagnosis for hemophilia A[J];Chinese Journal of Hematology;2001-03
10 ChenZhong,FanYu,ZhuNingning,etal.NationalLaboratoryofMedicalMolecularBiology.DepartmentofBiochemistryandMolecularBiology,InstituteofBasicMedi-calSciences,ChineseAcademyofMedicalSciences,Beijing,100005;Studyonthepolymorphismofintron13(CA)nrepeatwithinFⅧgeneinChineseanditsapplicationforthediagnosisofhemophiliaA[J];CHINESE JOURNAL OF HEMATOLOGY;1996-03
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 WANG Zhan-yong LIANG Yan ZHOU Yan XIAO Bai LIU Jing-zhong Basic Medical Research Center of Capital Medical University Affiliated Chaoyang Hospital,Beijing 100020,China;Analysis of X ba Ⅰ polymorphism of F Ⅷ gene and its application on prenatal diagnosis for hemophilia A[J];Chinese Journal of Hematology;2006-03
2 FENG Da-wei,YANG Lin-hua,GUO Zhi-ping.Department of Hematology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Detection and analysis of polymorphism of ST14 site in hemophilia A patients and their family[J];Chinese Remedies & Clinics;2011-07
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Wu xinyao Luo Chaoquan Yang Yinghao Liu Zhaowen Sun yat-sen University of Medical Sciences, Guangzhou;The STUDY OF HUMAN DNA FINGERPRINTS[J];Chinese Journal of Forensic Medicine;1989-04
2 Jin Chunlian,Lin Changhun,JiangLi,et al(Dept.of Medical Genetics);PRENATEL GENE DIAGNOSIS 0F HEMOPHILIA A BY PCR RFLPs ANALYSIS[J];Journal of China Medical University;1993-S1
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