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《CHINESE JOURNAL OF MEDICAL GENETICS》 1999-05
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Homozygous deletion of CDKN2/p16 gene in lung cancers

SU Changqing *, YE Yukun, CAO Xiangrong, SHAN Xiangnian. * Molecular Biological Laboratory of Nanjing 81 Hospital, Nanjing 210002 P.R.China. E mail:sucq@jlonline.com  
Objective To study the relationship between CDKN2/p16 gene homozygous deletion and lung cancer progression.Methods Improved multiplex PCR technique was applied to detect deletion of CDKN2/p16 gene exon 1 and exon 2 in 89 cases of lung cancers. Results Gene deletion rate was increased by the improved PCR technique. Exon 1 and exon 2 deletion rates were 19.1%(17/89) and 22 5% (20/89) respectively, with total rate of exon 1 and/or exon 2 deletion 25.8%(23/89). Deletion of CDKN2/p16 gene occurred in non small cell lung carcinoma (NSCLC) and was related to metastasis and progressive stage.Conclusion Abnormality of CDKN2/p16 gene is a genetic factor for NSCLC susceptibility, and may paly a role to some extent in NSCLC malignant progression.
【Fund】: 国家九五重点科技项目;国家自然科学基金
【CateGory Index】: R734.2
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