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《Chinese Journal of Laboratory Medicine》 2004-01
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Antimicrobial resistance of clinical bacteria in national surveillance network in 2002

MA Yue, LI Jing-yun, ZHANG Xin-mei, ZHANG Li, HU Chang-qin, JIN Shao-hong.National Institute for the Control of Pharmaceutical and Biological Products, National Center for Surveillance of Antimicrobial Resistance, Beijing 100050, China  
Objective To investigate the antimicrobial resistance of clinical isolates in national surveillance network,where 57 tertiary hospitals located in 8 provinces, metropolitans and municipality were involved. Methods Disc diffusion test (K-Bmethod) was used to study the antimicrobial resistance. WHONET 5 was applied foranalysis. Results In the period of study in 2002, 40 379strains were collected which were the first isolate from each patient, E. coli, P. aeruginosa, K.pneumoniae, S.aureus and S. epidermidis were the most common strains among the isolates, Resistant rates of Methicillin-resistant S. aureus (MRSA) and methicillin- resistant coagulase-negitive staphylococci (MRCNS) were higher than that of methicillin-susceptible S. aureus (MSSA) and methicillin-susceptible coagulase-negitive staphylococci (MSCNS) to antimicrobial agents commonly used in clinic; Most of E. faecalis isolates remained susceptible to penicillin and ampicillin.The resistant rate of E. faecium isolates were higher than that of E. faecalis to penicillin, ampicillin, high level gentamicin and streptomycin; Resistant rate of S. pneumoniae was 24.8% to penicillin and over 60% to macrolide antibiotics such as erythromycin and azithromycin. Most of isolates of Enterobacteriaceae were susceptible to both imipenem and meropenem. The incidences of E.coli and K. pneumoniae producing extended spectrum beta- lactamase isolates were 18.2% and 22.6%, respectively; Except for E.coli , less than 30%(6.0%~29.7%) of Enterobacteriaceae isolates were resistant to ciprofloxacin and levofloxacin; 19.1% and 15.2% of P. aeruginosa isolates were resistant to imipenem and meropenem, whereas the isolates of A. baumannii were susceptible to carbapenems. Conclusions Antimicrobial resistance of clinical isolates threatens the success of infectious disease treatment. It is very important to promote the rational use of antimicrobial agents so that resistance is minimized and take effective containment for the control of the problem.
【CateGory Index】: R446.5
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