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《NATIONAL MEDICAL JOURNAL OF CHINA》 2000-01
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Peroxynitrite mediated acute lung injury induced by lipopolysaccharides in rats

GUZhenyong ,LING Yiling,CONGBin ,etal DepartmentofPathophysiology,HebeiMedicalUniversity ,Shijiazhuang 0 5 0 0 17, China  
Objective Toexploretherolesofperoxynitrite(ONOO-)inacutelunginjuryinducedby lipopolysaccharides (LPS) Methods Nitrotyrosine (NT) ,aspecificmarkerofinvivoONOO-production ,was detectedwithimmunohistochemicaltechniqueinratlungduringendotoxinshock (LPS 5mg/kgiv) Lung coefficient(LC) ,lungwet/dryweightratio (W/D) ,thecontentsofwaterandEvansblue(EB)inlungswere measuredafterintratrachealinsufflationofONOO-withdifferentdoses Monastralblue (MB) labelledblood vesselsandpathologicalchangesinlungswereexaminedunderalightmicroscope Results After 2or 6hoursof LPSintravenousadministration ,severelunginjuryandpositivesignalsofNToccurredwiththelatterlocatedinthe pulmonarymacrophages,endothelia ,subendothelialandmuscularlayersofthepulmonaryartery Administrationof exogenousONOO-causeddose dependentincreaseinLC ,W /D ,waterandEBcontentsandinthenumberofMB labelledbloodvesselsinratlungs,togetherwithsignificantpathologicalalterationssuchasdiffusealveolar collapse ,capillarycongestionintheseptaandfocalhemorrhage Conclusion Intheearlystageofendotoxin shock,severelunginjuryandONOO-productionsimultaneouslyexist,andexogenousONOO-couldinduce significantdysfunctionofmicrovascularendothelialbarrierandlunginjury,indicatingthatONOO-generationin vivomaybeinvolvedinthepathogenesisofacutelunginjury
【Fund】: 国家自然科学基金资助项目!( 3 9870 3 17)
【CateGory Index】: R363
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【References】
Chinese Journal Full-text Database 10 Hits
1 Wang Xiaoyuan, Xia Zhongyuan, Du Daping,et al Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan 430060, China;Role of HO-1/CO in Lipopolysaccharide-induced Acute Lung Injury and the Effect of Sodium Nitroprusside on It[J];Journal of Hubei Medical University;2005-01
2 CAO De-quan~(1,*),CHEN Yan-ping~(1),CHANG Ye-tian~(1),LI Yong-guo~(2)(1.Department of Anesthesiology;2.Department of General Surgery,Second Xiangya Hospital,Central South University,Changsha 410011,China);Effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats[J];Journal of Central South University(Medical Sciences);2006-01
3 ;Effects of the Extract of Gingko Leaf Ginaton on Acute Lung Injury Caused by Lipopolysaccharide in Mice[J];Guiding Journal of TCM;2006-08
4 WANG He-mei,HUANG Chun-qian,ZHANG Xian-cheng,QU Wen-sheng,SUN Xiao-hong, DING Ri-gao,RUAN Jin-xiu(National Beijing Center for Drug Safety Evaluation and Research,Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China);The time-course effect of perfluoroisobutylene inhalation on endogenous nitric oxide and its synthases activity in rats[J];Bulletin of the Academy of Military Medical Sciences;2010-06
5 CHENG Shu bang, HONG JIAN qing, SHEN Mao xing (Department of General Surgery,The Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006,China);The Study on Nitric Oxide Increase Injury of Rabbit Liver during Ischemia-Reperfusion[J];Acta Academiae Medicinae Jiangxi;2001-04
6 GU Zhen Yong, LING Yi Ling , LI Shu Jin, MENG Ai Hong, ZHANG Jun Lan (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);Properties of peroxynitrite-induced relaxation in rabbit pulmonary artery in vitro[J];Acta Physiological Sinica;2001-04
7 GU Zhen-Yong~1,2, LING Yi-Ling~2, XU Xiao-Hu~1, MENG Ai-Hong~2, LI Shu-Jin~2 1 Shantou University Medical College, Shantou 515031; 2 Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Effect of peroxynitrite on the reactivity of rabbit pulmonary arteries in vitro[J];Acta Physiological Sinica;2003-04
8 GU Zhen-Yong~1,2, LING Yi-Ling~2, XU Xiao-Hu~1, ZHU Tie-Nian~2 , CONG Bin~2 1 Shantou University Medical College, Shantou 515031; 2 Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Endogenous peroxynitrite mediates lipopolysaccharide-induced injury in cultured pulmonary artery endothelial cells[J];Acta Physiological Sinica;2003-04
9 GAO Ju 1, ZENG Bangxiong 1, ZHOU Luojing 2,YUAN Shiying 1, ZHANG Shihai 1 1Department of Anesthesiology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 2Department of Child and Adolescent Health and Maternal Care, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022;Therapeutic Effect of Propofol in the Treatment of Endotoxin-induced Shock in Rats[J];华中科技大学学报(外文版);2003-03
10 GUO Zhengming1,CHEN Yi2,LIU Huijun2,XIAO Yuequn1,SONG Haipeng1,WANG Zhaozhao1,QU Xiaolin1,LUO Ziqiang2(1.Department of Basic Science,Hunan Traditional Chinese Medicine College,Zhuzhou Hunan 412012;2.Department of Physiology,Xiangya School of Medicine,Central South University,Changsha 410078,China);Ginkgo biloba extract (Ginaton) attenuates acute lung injury induced by lipopolysaccharide in mice[J];International Journal of Pathology and Clinical Medicine;2009-04
【Citations】
Chinese Journal Full-text Database 1 Hits
1 LING YI-LING AND SHAN-SHENG(Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017)WANG LE-FENG,ZHANG JUN-LAN WAN MEI AND HAO RONG-LI;CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8)REVERSES EXPERIMENTAL ENDOTOXIN SHOCK[J];ACTA PHYSIOLOGICA SINICA;1996-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LING Yi-ling,HUANG Xin-li(Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China);Importance of the role of endogenous anti-shock material in shock[J];Journal of Traumatic Surgery;2008-03
2 XU Shun-Jiang,GAO Wei-Juan ,YAO Yu-Xia,GU Zhen-Yong ,CONG Bin (. Department of Pathophysiology,Hebei Medical University,Shijiazhuang 05007,China; 2. Hebei Center of Disease Control);Effect of lipopolysaccharides on expression of cholecystokinin receptor mRNA in rat pulmonary interstitial macrophages[J];Academic Journal of Second Military Medical University;2003-11
3 GAO Feng,GU Zhen-yong,PING Jing,LIU Xia,ZHAO Li,XU Jin-rong,NI Zhi-yu,CONG Bin,LING Yi-ling((Department) of Forensic Medicine, Heibei Medical University,Shijiazhuang 050017,China);Inhibitive effect of cholecystokinin octapeptide on iNOS expression induced by lipopolysaccharide in ECV-304[J];Acta Academiae Medicinae Militaris Tertiae;2006-19
4 MA Li-Qin, GU Zhen-Yong, DONG Guo-Kai, LI Na, GAO Feng, LIU Xia, MA Chun-Ling, CONG Bin, LING Yi-Ling Department of Forensic Medicine and Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Effect of cholecystokinin octapeptide on LPS-induced SOD mRNA expression and increase of NF-κB activity in rat vascular smooth muscle cells induced by LPS[J];Journal of the Fourth Military Medical University;2006-20
5 JIN Yu huai ,ZHAO Zhan sheng,XU Jin rong,LIU Pin li,LI Shu jin,LING Yi ling,CONG bin. Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China Corresponding author:CONG bin,050017,Department of Pathophysiology,Hebei Medical University,Shijiazhuang,China;Effects of cholecystokinin octapeptide-8 on the proliferation of rat fibroblast-like synovial cells and its possible molecular mechanism[J];Chinese Journal of Rheumatology;2003-03
6 MA Liqin1,2,LAI Maode1,2,ZHOU Ren1,ZHU Youfa1 1.Research Institute of Pathology and Forensic Medicine of Zhejiang University medical college,Hangzhou 310058,China;2.Forensic Science Identification Center of Zhejiang University,Hangzhou 310058,China;The expression of CCK in atherosclerotic plaque of coronary artery of autopsy[J];Chinese Journal of Forensic Medicine;2010-04
7 ZHAO Zhan sheng, JIN Yu huai, XU Jin rong, et al . (Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017, China);Effect of cholecystokinin octapeptide on IL-6 secretion by rat synovial cell line[J];Basic Medical Sciences and Clinics;2003-01
8 NI Zhi-yu, LI Shu-jin, CONG Bin, YAO Yu-xia, WANG Chun-yan(The School of Basic Medical Sciences,Hebei Medical University,Shijiazhuang 050017,China);Inhibitory effect of CCK-8 on the expressions of TLR4 and IL-1β in LPS-induced pulmonary interstitial macrophages of rats[J];Basic Medical Sciences and Clinics;2005-02
9 HAO Li-na ~(1),WANG Qiu-hong ~(1),LING Yi-ling ~(1),MENG Xiang-yan ~(1),ZHANG Xiao-jing ~(1),LIANG Jun-qing ~(1),XIAN Xiao-hui ~(1),HE Shou-zhi ~(2)(1.Department of Pathophysiology of Hebei Medical University,Shijiazhuang,050051;2.Department of Ophthalmology of P.L.A.General Hospital,Beijing,100866);Effect of cholecystokinin octapeptide on diabetic cataract of rats[J];Basic Medical Sciences and Clinics;2005-07
10 GU Zhen Yong (Department of Pathophysiology, Hebei Medical University, [WT5”BZ]Shijiazhuang 050017) [WT5HZ];Peroxynitrite-Mediated Pulmonary Vascular Injury Induced by Endotoxin and the Protective Role of Cholecystokinin[J];Progress In Physiological Sciences;2001-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LI Yu Ming, LIU Jun Chang, ZHANG Min, ZHENG Xin Cheng, WU Li Ling, SHI An Yun, et al (Department of Pathophysiology, Beijing Medical University, Beijing 100083);Alterations of heme oxygenase in cardiovascular system during sepsis[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1999-06
2 QI Jian Guang 1, DU Jun Bao 1, GUO Zhi Liang 1, ZHAO Bin 2, ZHANG Qin You 1,ZENG He Ping 1, TANG Chao Shu (1 Department of Pediatrics, 3. Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China; 2;L-arginine regulates hypoxic pulmonary vascular structural remodeling and pulmonary artery smooth muscle cell apoptosis in rats[J];Journal of Beijing Medical University;2001-04
3 DU Jun Bao 1, CHEN Xiao Bo 1, GENG Bin 2, JIANG Hong Feng 2, TANG Chao Shu 2 (1. Department of Pediatrics; 2.Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing 100034, China);Hydrogen sulfide as a messenger molecule in cardiovascular system[J];Journal of Beijing Medical University;2002-02
4 DU Junbao 1△ , YAN Hui 1, TANG Chaoshu 2 (1 Department of Pediatrics, 2 Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China);Endogenous H_2S is involved in the development of spontaneous hypertension[J];Journal of Beijing Medical University;2003-01
5 ZHANG Chunyu 1, DU Junbao 1△ , BU Dingfang 2, YAN Hui 1,TANG Xiuying 3, SI Qin 4,TANG Chaoshu 5 (1.Department of Pediatrics,2.Central Laboratory, 3.Laboratory of Electron Microscopy, 5.Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing 100034,China;4.Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences);The regulatory effect of endogenous hydrogen sulfide on hypoxic pulmonary hypertension[J];Journal of Peking University(Health Sciences);2003-05
6 SHI Lin 1, DU Junbao 1△ , PU Dingfang 2,QI Jianguang 1,WEI Bing 1, TANG ChaoShu 3, TANG Xiuying 4(1 Department of Pediatrics, 2 Center Laboratory,3 Institute of Cardiovascular Research, 4 Laboratory of Electric Microscopy, Peking University First Hospital, Beijing 100034, China);Effects of high pulmonary blood flow on pulmonary vascular structure and the gene expression of cystathionine-γ-lyase[J];Journal of Peking University(Health Sciences);2003-06
7 ZHANG Qing you 1, DU Jun bao 1, SHI Lin 1,ZHANG Chun yu 1, YAN Hui 1, TANG Chao shu 2 (1.Department of Pediatrics, 2.Institute of Cardiovascular Research,Peking University First Hospital, Beijing 100034, China);Interaction between endogenous nitric oxide and hydrogen sulfide in pathogenesis of hypoxic pulmonary hypertension[J];Journal of Peking University(Health Sciences);2004-01
8 GENG Bin 1 , YAN Hui 2, ZHONG Guang zhen 3, ZHANG Chun yu 2, CHEN Xiao bo 2, JIANG Hong feng 1, TANG Chao shu 1 , DU Jun bao 2△ (1. Department of Physiology, Peking University School of Basic Medical Sciences ; 2. Department of Pediatrics, Peking University First Hospital, Beijing 100034, China; 3. Department of Cardiology, Peking University Third Hospital);Hydrogen sulfide: a novel cardiovascular functional regulatory gas factor[J];Journal of Peking University(Health Sciences);2004-01
9 YAN Hui 1, DU Jun-bao 1△ , TANG Chao-shu 2 (1.Department of Pediatrics, 2.Institute of Cardiovascular Research,Peking University First Hospital, Beijing 100034, China);Possible effects of endogenous hydrogen sulfide on aortic remodeling in hypertensive rats[J];Journal of Peking University(Health Sciences);2004-03
10 CHEN Xiao bo 1,DU Jun bao 1△ , ZHANG Chun yu 1 , TANG Chao shu 2,ZHOU Wei jin 2 (1.Department of Pediatrics, 2.Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China );Effect of hydrogen sulfide, a new gaseous signal molecule, on pulmonary vascular smooth muscle cell apoptosis in rats[J];Journal of Peking University(Health Sciences);2004-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 QU Ying(Department of Neurology,Chongqing Emergency Medical Center,Chongqing 400014,China);Research on treatment effects of Ginkgo Biloba Extract on chronic cerebral circulation insufficiency[J];Chongqing Medicine;2010-18
2 WANG Liang(P.E.Department,The North University for Ethnics,Yinchuan,Ningxia 750021);On the Current Research and Existing Problems of Nitric Oxide in Cardiovascular System in Exercise Training[J];Journal of Hunan First Normal College;2009-01
3 WANG Hui-yun1,YAN Jun1,XIANG Jian1,ZHAO Li-xiang1,GU Zhen-yong1,2(1.Department of Forensic Medicine,Medical College of Soochow University,Suzhou 215123,China;2.Department of Forensic Medicine,Medical College of Nantong University,Nantong 226001,China);Effect of Soft Tissue Crush Injury on Tensions of Thoracic Aortic Rings in Rats[J];Journal of Forensic Medicine;2011-02
4 ZHANG Jianxin,LI Lanfang,SHANG Tao.Hebei Academy of Medical Sciences,Shijiazhuang 050021;Effect of aminoguanidine and L-arginine on mitochondria injury in acute lung injury rats induced by endotoxin[J];Hebei Medical Journal;2009-04
5 ZHAO Shuangping,WU Jiao,GUO Qulian,ZHANG Zhong,YE Zhi(Intensive Care Unit,Xiangya Hospital,Central South University,Changsha 410008,China);Effect of different concentrations of sevoflurane pretreatment on acute lung injury induced by endotoxin in rats[J];Journal of Central South University(Medical Science);2010-09
6 YU Hai,LI Li,HE Li-ying(Department of Ophthalmology,Affiliated Second Hospital,Chongqing Medical University,Chongqing 400010,China);Protection effect of propofol on rabbit's lens oxidative stress[J];Laser Journal;2009-02
7 DU Li- zhong. The Children's Hospital,Zhejiang University School of Medicine,Zhejiang Hangzhou 310003,China;Advances in diagnosis and treatment on neonatal persistent pulmonary hypertension[J];The Journal of Clinical Pediatrics;2006-11
8 YU Xiao-yan, LI Jie (Physical Education School of Northwestern Normal University, Lanzhou, Gansu, 730070);On the status quo and development of the research on the relationship of nitric oxide exercise training[J];Liaoning Sport Science and Technology;2008-01
9 PENG Lina1,WANG Yan-hong2,LIU Lei3(1.Physical Education Dept.of Langfang Normal College,Langfang Hebei,065000;2.Physical Education School of Hebei Normal College,Shijiazhuang Hebei 050016;3.Xingtai Zuiguang Middle School,Xingtai Hebei 054001);About the influences of different intensity exercises to the nitrogen monoxide in body[J];Liaoning Sport Science and Technology;2010-02
10 MENG Ai-hong,WANG Bao-fa,YUAN Ya-dong,et al.Department of Respiratory Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050017,China;Clinical Analysis of 14 Cases with Acute Drug-induced Lung Injury[J];Chinese General Practice;2009-20
China Proceedings of conference Full-text Database 2 Hits
1 UANG Junqing, WU Yiling, WANG Hongtao ,et al. HeBei YiLing Pharmaceutical Research Institute , Shijiazhuang 050035, China;The effect of sports fatigue on endothelium cell of rats and antioxidative protection of Tongxinluo super[A];[C];2006
2 LIANG Junqing, WU Yiling, JIA Zhenhua , et al. Hebei Yiling Pharmaceutical Research Institute , Shijiazhuang 050035, China;Protection of TongXinLuo Powder[A];[C];2006
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 MEI LIN;HAN JI-SHENG(Department of Physiology,Beijing Medical University,Beijing100083);CHOLECYSTOKININ-OCTAPEPTIDE ANTAGONIZES THE CENTRAL DEPRESSIVE EFFECT OF OPIOID PEPTIDES IN RATS[J];Acta Physiological Sinica;1991-02
2 Ling Yi-Ling, et al Department of Pathophysiology, Hebei Medical College, Shijiazhuang;The effect of naloxone on the electric activity of sympathetic nerve in rabbit SMAO shock[J];Chinese Journal of Pathophysiology;1986-02
3 Wang Le-Feng, Huang Shan-Sheng, et al Department of Pathophysiology, Medical College of Hebei, Shi jiazhuang;Clearance and detoxification of endotoxin by lung[J];Chinese Journal of Pathophysiology;1992-02
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