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Peroxynitrite mediated acute lung injury induced by lipopolysaccharides in rats

GUZhenyong ,LING Yiling,CONGBin ,etal DepartmentofPathophysiology,HebeiMedicalUniversity ,Shijiazhuang 0 5 0 0 17, China  
Objective Toexploretherolesofperoxynitrite(ONOO-)inacutelunginjuryinducedby lipopolysaccharides (LPS) Methods Nitrotyrosine (NT) ,aspecificmarkerofinvivoONOO-production ,was detectedwithimmunohistochemicaltechniqueinratlungduringendotoxinshock (LPS 5mg/kgiv) Lung coefficient(LC) ,lungwet/dryweightratio (W/D) ,thecontentsofwaterandEvansblue(EB)inlungswere measuredafterintratrachealinsufflationofONOO-withdifferentdoses Monastralblue (MB) labelledblood vesselsandpathologicalchangesinlungswereexaminedunderalightmicroscope Results After 2or 6hoursof LPSintravenousadministration ,severelunginjuryandpositivesignalsofNToccurredwiththelatterlocatedinthe pulmonarymacrophages,endothelia ,subendothelialandmuscularlayersofthepulmonaryartery Administrationof exogenousONOO-causeddose dependentincreaseinLC ,W /D ,waterandEBcontentsandinthenumberofMB labelledbloodvesselsinratlungs,togetherwithsignificantpathologicalalterationssuchasdiffusealveolar collapse ,capillarycongestionintheseptaandfocalhemorrhage Conclusion Intheearlystageofendotoxin shock,severelunginjuryandONOO-productionsimultaneouslyexist,andexogenousONOO-couldinduce significantdysfunctionofmicrovascularendothelialbarrierandlunginjury,indicatingthatONOO-generationin vivomaybeinvolvedinthepathogenesisofacutelunginjury
【Fund】: 国家自然科学基金资助项目!( 3 9870 3 17)
【CateGory Index】: R363
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