Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《National Medical Journal of China》 2003-12
Add to Favorite Get Latest Update

Changes of clinical aspect of primary liver cancer in China during the past 30 Years -- control study for 3250 cases with primary liver cancer

YANG Bing-hui, XIA Jing-lin, HUANG Li-wen, TANG Zhao-you, CHEN Min-shan, LI Jin-qing, LIANG An-min, MO Qin-guo, LU Hui-shan, DAI Chao-liu, YAN Lü-nan, YU Zhi-jian, RAO Rong-sheng, LI Le-qun, SU Zhi-xiong, FANG Zhuang-wei. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China  
Objective To study the changes of the clinical aspects of primary liver cancer (PLC) during the past 30 years. Methods The clinical data of 3 250 patients with PLC, from 10 regions of China were collected, analyzed, and compared with the clinical data of 3254 PLC cases 30 years before. Results The 3 250 patients were aged 1~80, with an average age of 49.1 years, younger than those 30 years before (43.7 years). The male to female ratio was 2.3∶1, lower than that 30 years before (7.7∶1). 73.5% of them sought medical advice within 3 months after the onset in comparison of 63.8% 30 years before. Compared with those 30 years before the symptoms and signs were alleviated in general. The HBsAg positive rate was 81.0%, the HCV-Ag positive rate was 13.2%, and the alpha-fetoprotein positive rate was 75%. 1912 cases underwent pathological examination of which 91.8% were diagnosed as with hepatocellular carcinoma. The overall resection rate was 46,3%. Those of early, median, and late stages accounted for 29.9%, 51.5%, and 18.6% respectively in comparison with the rates of 0.4%, 47.0%, and 52.6% 30 years before. The one-year survival rate, three-year survival rate, and five-year survival rate were 66.1%, 39.7%, and 32.5% respectively for the whole group, 93.5%, 70.1%, and 59.1% for the early stage patients, and 65.3%, 30.5%, and 23.5% respectively for the median stage patients. The half-year survival rate and one-year survival rate of the late stage patients were 52.5% and 14.7% respectively. Compared with the data 30 years before a lower percentages of the patients died of hepatic coma, hemorrhage of upper digestive tract and hemorrhage due to rupture of tumor, and a higher percentage of then died of asthenia universalis and other causes. Conclusion In comparison with the situation 30 years ago, PLC can be diagnosed earlier. More patients undergo resection. The prognosis of PLC has been improved greatly.
【CateGory Index】: R735.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 Wang Wenjing;Zhao Long;Feng Xiansong;Chen Qing;Department of Hepatobiliary Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology;;Analysis of re-resection for recurrent hepatocellular carcinoma[J];腹部外科;2016-03
2 ZUO Tai-yang;XU Shu-ling;ZHANG Zhong-tao;Department of CT Room,Qilu Hospital of Shandong University Pingyi Branch;;Clinical application of CT guided microwave ablation for the treatment of hypovascular liver cancer[J];放射学实践;2015-11
3 Xiao Wenbo;Liu Hao;Digestion Center,University-town Hospital,Chongqing Medical University;;Comparison of the recent therapeutic effect for large primary liver cancer between radiofrequency ablation and high intensity focused ultrasound[J];临床超声医学杂志;2015-04
4 ZHOU Yong-xu;LU Chao-yang;PAN Bo;MU Xiao-feng;LIU Lian-xin;The First Affiliated Hospital of Harbin Medical University;The Third Affiliated Hospital of Harbin Medical University;;The Progress of Radiofrequency Ablation for the Treatment of Liver Cancer[J];现代生物医学进展;2015-05
5 ZuYuqi;Xue Ping;Jiang Xiaofeng;Wen Zilong;Zhang Dawei;Department of Hepatobiliary Surgery, the Second Hospital of Guangzhou Medical University;;Clinical research on treating advanced stage hepatocarcinoma with DC-CIK immunotherapy combined with TACE interventional therapy[J];岭南现代临床外科;2014-05
6 Fan Wenzhe;Zhang Yingqiang;Wang Yu;Yao Xuehua;Yang Jianyong;Li Jiaping;Department of Interventional Radiology,The First Affiliated Hospital,Sun Yat-sen University;;An analysis of clinical factors in patients with hepatocellular carcinoma after transcatheter arterial chemoembolization complicated with diabetes[J];中华医学杂志;2014-33
7 Jia Honglian;Huang Caiyun;Song Lijun;Li Shilong;Han Sugui;Wang Xiaorui;Zhang Bao;Department of Laboratory,Leting County Hospital;;Diagnostic value of serum AFP-L3,GP73 and GGT combined detection in hepatocellular carcinoma[J];肿瘤研究与临床;2014-07
8 Li Yuan;Xie Chunming;Feng Duiping;Yang Minling;Pang Ningdong;Chen Yi;;Observation of Hepatic artery Embolism Chemotherapy Combined with Microwaveablation Treatment of huge Hepatocellular Carcinoma[J];中国药物经济学;2014-06
9 YU Mei;MEI Qi;NI Juan;QIN Chen;XU Xiang-yong;FU Qing-yin;SHA Hong-fang;ZHAI Ling-yun;WANG Gang;ZHANG Jing;Department of Ultrasound,Shanghai Dahua Hospital;;Surveillance and early diagnosis of small hepatocellular carcinoma with contrast-enhanced ultrasonography[J];中国癌症杂志;2014-03
10 Ke Yang;Zhong Jianhong;Guo Zhe;Liang Yongrong;Li Lequn;Xiang Bangde;Department of Hepatobiliary Surgery,Tumor Hospital,Guangxi Medical University;;Comparison liver resection with transarterial chemoembolization for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma patients on long-term survival after SPSS propensity score matching[J];中华医学杂志;2014-10
China Proceedings of conference Full-text Database 1 Hits
1 Zhao Ming1,Wu Pei-hong1,Zeng Yi-xin1,Xia Jian-chuan2,ZHANG Fu-jun1,Xian li-jian3,Zhang Yu-ping4 Zhou Kun5,Fan Wei-jun1,Zhang Liang1,Gao Fei1,Zhou Qi-ming1 1.Department of Imaging and Interventional Radiology,Cancer hospital,Sun Yat-sen University,Guangzhou Guangdong 51 0060,China 2.State Key Laboratory of Oncology in Southern China,Guangzhou Guangdong 510060,China;CIKs infusion to lower recurrence rates of hepatocellular carcinoma after TACE sequentially combined RFA:a randomized trial[A];[C];2011
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Jae Hyun Han;Dong Goo Kim;Gun Hyung Na;Eun Young Kim;Soo Ho Lee;Tae Ho Hong;Young Kyoung You;Department of Surgery, The Catholic University of Korea, Seoul St.Mary’s Hospital;;Evaluation of prognostic factors on recurrence after curative resections for hepatocellular carcinoma[J];World Journal of Gastroenterology;2014-45
2 ZHU Daojing;ZHOU Kun;Department of Biomedical Engineering,Chongqing Medical University;;High intensity focused ultrasound for hepatocellular carcinoma:current development and progress[J];临床超声医学杂志;2014-04
3 Zheng-Gui Du;Yong-Gang Wei;Ke-Fei Chen;Bo Li;Department of Liver and Vascular Surgery,Liver Transplantation Center,West China Hospital,Sichuan University;;Risk factors associated with early and late recurrence after curative resection of hepatocellular carcinoma: a single institution's experience with 398 consecutive patients[J];Hepatobiliary & Pancreatic Diseases International;2014-02
4 LI Ling-fei,LI Kai(Eighth Team of Cadet Brigade,Third Military Medical University,Chongqing 400038,China);Hepatic segments 3D reconstruction based on the characters of hepatic veins[J];局解手术学杂志;2012-05
5 WU Fei-xiang,WANG Fang-wei,MA Liang,HUANG Sheng-xin,HUANG Shan,ZHAO Yin-nong(Department of Hepatobiliary Surgery,Affiliated Tumor Hospital of Guangxi Medical University;Graduate School of Guangxi Medical University,Nanning,530021,P.R.China);Short-term therapeutic effect of re-operation on 246 patients with postoperative recurrent primary hepatic carcinoma[J];中国癌症防治杂志;2012-02
6 HUANG Cai-yun,HAN Su-gui,ZHANG Jing-hua,WANG Xiao-rui, LI Shi-long,ZHOU Xiu-yan(Department of Nuclear Medicine,The People's Hospital of Tangshan of Hebei Union University,Tangshan 063000,China);Detection of AFP-L3 in Diagnosis of Hepatocellular Carcinoma[J];标记免疫分析与临床;2012-03
7 LJialing,DU Duanming,LIU Pengcheng,CHEN Junhui,ZHOU Ruming, CHEN Zaizhong,YU Hongjian,XIONG Yu,CHENG Xianyi,DAI Luping (Department of Radiology,Peking University Shenzhen Hospital, Shenzhen,Guangdong Province 518000,China);The analyses of impact factors prognostic of primary hepatocellular carcinoma with transcatheter arterial chemoembolization[J];实用放射学杂志;2012-01
8 Ministry of Health of the People's Republic of China;Diagnosis,management,and treatment of hepatocellular carcinoma(V2011)[J];临床肝胆病杂志;2011-11
9 ZHANG Yun-peng~*, GUO Su-tang,WANG Fu-hua,WU Yu-mei,YANG Rui-hong,WANG Chun-yan.* College of Postgraduate, Shanxi Medical University,Taiyuan 030001,China;Preliminary study of diagnosis of hepatocellular carcinoma by protein chip technique[J];肿瘤研究与临床;2011-10
10 SHEN Zhao-yu1,WANG Ji-ming2,HU Xiao-kun1 1.Department of Radiology,Qi Lu and Ping Yi Union Hospital of Shandong College,Shandong 273300,P.R.China2.Department of Radiology,Pingyin Hospital of Shandong,Shandong 250400,P.R.China;Application of treatment with radiofrequency ablation in primary hepatocellular carcinoma of poorly blood supplying by CT guide[J];医学影像学杂志;2011-07
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LI Jingxian;JIANG Yanping;WANG Jiaping;GUO Li;ZHU Li;LIU Rui;ZHAO Ruimin;TONG Yuyun;JIAN Yuanxi;Department of Radiology,the School Hospital of Kunming Medical University;Department of Radiology,the Second Affiliated Hospital of Kunming Medical University;;The combination of sephedex and docetaxel used in intervention for clinical treatment of primary liver cancer[J];实用放射学杂志;2017-05
2 Xia Min;Zhang Ping;Sheng Kaixiang;Jiang Hua;Zhang Xiaohui;He Yongchun;Xu Chunping;Chen Jianghua;Kidney Disease Center,the First Affiliated Hospital,College of Medicine,Zhejiang University;;Prognostic analysis of aged end-stage renal disease patients receiving hemodialysis and peritoneal dialysis[J];中华肾脏病杂志;2016-08
3 MA Xianshi;YI Lihua;CAO Peng;Department of General Surgery yYangxin Peoples Hospital;;Efficacy of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of primary hepatocellular carcinoma[J];临床外科杂志;2016-02
4 XIONG Jun;ZHANG Wei;JIAO Lin;CHI Zhen-hai;FU Yong;XIE Ding-yi;CHEN Ri-xin;Department of Acupuncture and Moxibustion,the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine;;Different Warm Sensations May Induce Different Therapeutic Effects in Primary Dysmenorrhea Patients Undergoing Moxibustion Treatment Based on Propensity Score:A Prospective Cohort Study[J];针刺研究;2015-06
5 Qin Feng;Li Wei;Shen Shiqiang;Department of Hepatobiliary Endoscopic Surgery,Renmin Hospital of Wuhan University;;Meta-analysis of TACE combined with PMCT in treatment of advanced liver cancer[J];国际外科学杂志;2015-10
6 XIAO Qing;Ultrasound Department,Mianyang Third People's Hospital;;Effect of Real Time Contrast Enhanced Ultrasound on Liver Cancer Radiofrequency Therapy[J];贵阳医学院学报;2015-11
7 WEI Gan-bao;Department of Radiation Oncology,Gaozhou Hospital;;Propensity Score-based Comparison of Long-term Outcomes with Concurrent DDP/5-Fu vs Docetaxel/DDP for Thoracic Esophageal Cancer Undergoing Radiotherapy[J];中山大学学报(医学科学版);2015-05
8 Liu Youde;Liu Jinping;Hua Zhengzhong;Wang Chunjuan;Qiang Chunqian;Zou Zhiqiang;Yu Jiguang;Yantai Infectious Disease Hospital;;The cumulative rate of HBeAg seroconversion in HBeAg positive chronic hepatitis B patients treated with telbivudine and entecavir after propensity score matching[J];中华实验和临床病毒学杂志;2015-04
9 LIU Jianyong;ZHOU Yonghe;LI Jia;LIU Yonggang;LU Wei;Tianjin Second People Hospital;;Correlation of histopathologic grading of hepatocellular carcinoma with its contrast-enhanced ultrasound[J];天津医药;2015-08
10 ZHANG Jian-gang;WANG Xia;ZHANG Ai-hong;MA Yi-nu-er;CHEN Jing-li;Department of Ultrasound,the Second Affiliated Hospital of Xinjiang Medical University;;The performance characteristics and the similarities and differences of cirrhotic ultrasound and enhanced computed tomography for the diagnose of small hepatocellular carcinoma in cirrhotic[J];中国肿瘤临床与康复;2015-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved