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《National Medical Journal of China》 2007-38
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Effect of chronic myocardial infarction on the distribution of β-adrenoceptors in heart:experiment with dogs

LI Jing-jie Qu Xiu-fen LI Ke-shen YU Yang XI Yang YUE Le WANG Gui-zhao HUANG Yong-lin Department of Cardiology,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China  
Objective To investigate the distribution of β-adrenoceptors at different sites of heart after myocardial infarction(MI).Methods 14 dogs were randomly divided into 2 equal groups:MI group, undergoing ligation of the left anterior descending coronary artery,and control group undergoing sham- operation.Four weeks later metoprolol,a β_1-adrenergie receptor antagonist,was injected intravenously. Doppler tissue imaging(DTI)was used to evaluate the peak systolic myocardial velocity(Sm)of the regions apical and basal to the infarction region before and after the injection.Then the dogs were killed with their hearts taken out.Reverse-transcriptase polymerase chain reaction was used to examine the mRNA expression of β_1-receptor and β_2-receptor in the non-infracted myocardial tissues apical and basal to the infarction region.Results The Sm values at the regions apical and basal to the infarction region of the MI group were 3.93±0.47 and 0.81±0.19 cm/s respectively,both significantly lower than those of the control group (10.84±1.97 and 5.85±1.15 cm/s respectively,both P0.05).After injection of metoprolol,the Sm values at the regions apical and basal to the infarction region of the MI group were 3.43±0.37 and 0.73± 0.14 cm/s respectively,not significantly different from those before the injection;however,the corresponding Sm values of the control group were 8.69±1.14 and 4.33±0.29 cm/s respectively,both significantly lower than those before the injection(both P0.05).The mRNA expression levels of β_1- receptor decreased in both apical and basal regions in the MI group compared with those in the control group, and the degree of expression decrease at the apical region was significantly greater than that at the basal region.However,there was no significant difference in the expression level of β_1-receptor mRNA between the apical and basal regions in the control group.There was no significant difference in the mRNA.expression of β_2-receptor in different regions of the heart in both groups.Conclusion After MI regional variation occurs for the β_1-receptor mRNA expression,but not to the β_2-receptor.
【Fund】: 国家自然科学基金(30470687)
【CateGory Index】: R542.22
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Chinese Journal Full-text Database 10 Hits
1 LI Jing-jie,QU Xiu-fen,SHEN Jing-xia,et al (Department of Cardiology,The First Clinical College,Harbin Medical University,Harbin 150001,China);Regional abnormal distribution of autonomic nerve and its effect on ventricular function[J];Journal of Harbin Medical University;2007-04
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9 XI Yang *,QU Xiu-fen,YU Yan-wei,LI Jing-jie,ZHAO Gang,HUANG Yong-lin. * Department of Cardiology,First Hospital of Harbin Medical University,Harbin 150001,China;Study of sympathetic neural remodeling after myocardial infarction in rats[J];Chinese Journal of Cardiac Arrhythmias;2004-03
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