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《Chinese Journal of Nosoconmiology》 2003-12
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Hospital-acquired Infections due to Coagulase-negative Staphylococci:A Clinical Analysis of 180 Cases

JIANG Xiao-ping, WEI Xue-fen,ZHAO Xian-ying,SU Fei (Affiliated Hospital, Anhui Medical University, Hefei 230022, China)  
OBJECTIVE To determine the clinical distribution and antimicrobial resistance of coagulase-negative staphylococci(CNS) isolated from hospital-acquired infections in our hospital. METHODS A total of 180 cases with hospital-acquired CNS infections in recent three years(1998-2000) were retrospectively studied and the CNS isolation rate was compared with that of former three years(1995-1997). RESULTS Of 1 044 hospital-acquired isolates, staphylococci accounted for 30.8%,CNS for 17.92%, both higher than those in former three years (P0.05 and P0.01 , respectively). Most CNS infected cases had serious underlying diseases and most CNS strains were isolated from samples of urine (87 strains) , burn wounds(56 strains) and sputum(26 strains). The CNS strains were resistant to multiple antibiotics but sensitive to vancomycin. The drug-resistant rate of CNS (except S.haemolyticus ) to rifampicin, trimethoprim/sulfamethoxazole and ciprofloxacin was relatively lower. CONCLUSIONS The result indicated that isolation rate of CNS in hospital-acquired infections is higher in recent years than in the past. CNS can cause infections of many sites and show multi-drug resistance.
【CateGory Index】: R181.3
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