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《Chinese Journal of Nosocomiology》 2006-07
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Mechanism of Aspergillus Infection During Hypoimmunity: An Experimental Research

SU Ming-quan,YUE Qiao-hong,YANG Liu,FAN Xin,ZHANG Jian-fang,HAO Xiao-ke,DING Zhen-ruo(Xijing Hospital,the Fourth Military Medical University,Xi′an,Shanxi 710032, China)  
OBJECTIVE To establish the animal model and investigate the lethal factor of aspergillosis infection(during) hypoimmunity.METHODS Methylprednisolone Na succinate was injected through rabbit′s ear vein.(Changes) in immune indexes were observed using PENIA method.Major organs of rabbit were dyed with PAS and processed pathologic analysis.RESULTS After 3d methylprednisolone Na succinate injection,several immune(indexes) declined when compared to before injection.Liver,kidneys,heart and lungs all had pathologic changes,especially kidneys and lungs.CONCLUSIONS Aspergillus infection can bring on pathologic changes in several(organs) during hypoimmunity.Mechanism research should be enhanced for it is important in diagnosis,therapy and control of aspergillus(infection).Clinician should attach importance to aspergillus infection.
【Fund】: 陕西省自然科学基金资助(2004C2-64)
【CateGory Index】: R519
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