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《Chinese Journal of Nosocomiology》 2007-10
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Pulmonary Infection due to Aspergillus:A Clinical and Drug Resistance Investigation

ZHOU Tie-li,PENG Ting-ting,LI Yu-ping,WU Ling-jian,WANG Sai-fang,LI Chao,ZHOU Wu(The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang 325000,China)  
OBJECTIVE To detect the susceptibility of Aspergillus to antifungal agents,and describe the correlated factors and outcome of pulmonary aspergillosis.METHODS Etest method was used to test the minimum inhibitory concentration(MIC) of itroconazole,ketoconazole,flucytosine,caspofungin,amphotericin B and fluconazole against Aspergillus.Eighteen pulmonary aspergillosis cases were retrospectively analyzed.RESULTS The MIC90 of caspofungin,itroconazole,and amphotericin B were 0.25,1.0,and 2.0 μg/ml,respectively.The MIC90 of ketoconazole,flucytosine and fluconazole were 32,32,and 256 μg/ml,respectively.Caspofungin had higher in vitro antimicrobial activity to all Aspergillus;itroconazole had higher in vitro antimicrobial activity to A.fumigatus and A.flavus than amphotericin B,but amphotericin B had higher in vitro antimicrobial activity to A.niger than itroconazole.Most cases were aging and had various underlying diseases.CONCLUSIONS Aging,underlying diseases and plentiful use of antibiotics are the most factors inducing Aspergillus infections,the mortality of pulmonary aspergillosis is high;itroconazole,caspofungin and amphotericin B had higher in vitro antimicrobial activity to Aspergillus,but various types antifungal agents have different in vitro antimicrobial activity against various types of Aspergillus.It is necessary to identify Aspergillus to species and perform antifungal susceptibility test among infected cases.
【CateGory Index】: R519
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