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《Chinese Journal of Nosocomiology》 2012-22
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Mohnarin report of 2011:monitoring of bacterial resistance in China

XIAO Yong-hong,SHEN Ping,WEI Ze-qing,CHEN Yun-bo,KONG Hai-shen, YANG Qing,ZHANG Wei-li,CHEN Xiao,LI Lan-juan(State Laboratory for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital, College of Medicine,Zhejiang University,Hangzhou,Zhejiang 310003,China)  
OBJECTIVE To investigate the resistance of clinical isolates from hospitals in China so as to provide clinical reference in the use of antibacterial agents.METHODS All the bacterial susceptibility results from 49 tertiary hospitals around China from 1st Jan,to 31st Dec,2011 were collected by unified protocol and the data was processed with software WHONET 5.6.The sensitive results from both disc diffusion and automatic microbiological system methods were acceptable.RESULTS A total of 118 868 bacterial isolates and their antibacterial susceptibility data were collected during the survey period,which included 34 208(28.8%) strains of gram-positive bacteria and 84 660(71.2%) strains of gram-negative bacteria.Staphylococcus(20 894 strains),Enterococcus(7977strains) and Streptococcus(4058 strains) were the top three gram-positive isolates,while Escherichia coli(21 780 strains),Klebsiella spp(15 097 strains),Pseudomonas aeruginosa(13928 strains) and Acinetobacter spp(13 592 strains) were the most common gram-negative isolates.The methicillin-resistant S.aureus,S.epidermidis and S.haemolyticus were 50.5%,82.6%,and 87.3%,respectively.The isolation rate of E.faecium was higher than that of E.faecalis,the drug resistance to the glycopeptide class of drugs was similar to the last monitoring;85.4% of S.pneumoniae strains were sensitive to penicillin.The detection rates of ESBLs-producing E.coli and K.pneumoniae were 71.2% and 50.3%,respectively.Enterobacteriaceae maintained the higher susceptibility to carbapenems,the drug susceptibility rate declined as compared with 2010.The non-fermenting bacteria were highly resistant to carbapenems,and the drug resistance rate of A.baumannii was increased.CONCLUSION The bacterial resistance of the clinical isolates is severe in China,especially the ESBLs-producing Enterobacteriaceae,and multidrug-resistant non-fermenting bacteria are prevalent.
【Fund】: 卫生行业科研专项项目(201002021)
【CateGory Index】: R446.5
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