Full-Text Search：
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF ONCOLOGY》 1997-01
Add to Favorite Get Latest Update

Effects of lcariin on the differentiation of HL-60 cells

Zhao Yong, Cui Zhengyan, Zhang Ling, et al. Shandong Provincial Qianfoshan Hospital, Jinan 250014  
Objective In order to search for new tumor differentiation inducer, the effects and mechanism of lcariin were studied. Methods Icariin is an monomer purified from Epimedium Koreanum Nakai. The differentiation of induction effects of lcariin were observed on the human promyelocytic leukemic cell (HL 60) by NBT reduction test, 125 I cAMP and 125 I cGMP double antibody radioimmune methods, scanning electronic microscopy technique. Results After treating HL 60 cells with lcariin at concentration 0.1g/L, reduction of NBT and cAMP/cGMP ratio were increased. There were many rugosities and ball like processes on the cell surface. Conclusion lcariin had the effects of induction of differentiation on HL 60 cells, the mechanism might be related to elevating the cAMP/cGMP ratio.
【Key Words】： Icariin Leukemia promyelocytic acute Cell differentiation Cyclic nucleoside
【CateGory Index】： R733.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 8 Hits
1 HOU Ji-rui~1, SHENG Ji-min~2, WANG Xiu-quan~1, TIAN Yi-xin~1,　WU Gou-ju~1 (1. College of Chinese Medicinal Material, Jilin Agricultural University, Changchun, Jilin 130118, China; 2. Forestry Bureau of Changbai County, Changbai, Jilin 134400, China );Advances in Studies on Herba epimedii[J];Journal of Jilin Agricultural University;2004-01
2 Zhang Hongjun(张洪钧), Chen Xinyi(陈信义), Sun Yingli(孙颖立)(Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100700);The Phenotype Reversion of Human Myelogenous Leukemic Cells Caused by Human Cord Blood Cytoplasm Treated with TCM Drugs for Clearing Away Heat and Nourishing Yin[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-05
3 SUN Jian-li Tutor:LIU Jia-xiang Shanghai University of Traditional Chinese Medicine;Survey of Mechanism Study on Pulmonary Cancer Treated by Chinese Medicine[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2001-01
4 MAI Shi-ren1,YUAN Pei-ying1,LIU Yi-po2,et al (1.Toronto College of TCM, Canada; 2. Toronto Anfutang National Medicine, Canada);Summing up and Feeling in Treating Tumor on TCM[J];Tianjin Journal of Traditional Chinese Medicine;2006-03
5 LI Xiu-nan 1,2 ,SUN Hai-hong 2,MA Run-yu 1,SU Zhi-guo 2* (1.School of Chemical Engineering,Beijing University of Chemical Technology,Beijing 100029,China;2.State Key Lab of Biochemical Engineering,Institute of Process Engineering,The Chinese Academy of Sciences,Beijing 100080,China);Chromatographic Separation of Icariin from Extract of Epimedii Herba by Macroporous Adsorption Resin[J];Natural Product Research and Development;2005-02
6 WANG Ting1,2,ZHANG Jin-chao2,3,CHEN Yao2,HUANG Feng1,4,YANG Meng-su2,XIAO Pei-gen1(1.Institute of Medicinal Plant Developrnent,Chinese Academy of Medical Sciences andPeking Union Medical College,Beijing 100094,China;2.Shenzhen Research Institute of City University of Hong Kong,Shenzhen,518057,China;3.Department of Chemistry,College of Chemistry & Environmental Science,Hebei University,Baoding 071002,China;4.State Key Laboratory of Chinese Medicine and Molecular Pharmacology,Shenzhen 518057,China);Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum[J];China Journal of Chinese Materia Medica;2007-08
7 HUA Bao jin (Guanganmen Hosptial,China Academy Of Traditional Chinese Medicine,Beijing 100053,China);Study on the Mechanism of Differentiation and Apoptosis of Tumor Cells Induced by Effective monomers of Chinese Medicina Herbs[J];China Journal of Basic Medicine In Traditional Chinese Medicine;2002-07
8 MIN Hong-bo WANG Jian-wen SUN Ji-hu Department of Ophthalmology,The 455 Hospital of PLA,Shanghai(200052);Effect of lcarlin on Inducing Apoptosis and Inhibiting Bcl-2 in Human Retinoblastoma[J];Chinese Journal of Integrated Traditional and Western Medicine;2003-S1
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SHAN Bao-en1, REN Feng-zhi2, LIANG Wen-jie1,3,ZHANG Jing1,Li Qiao-xia1, ZENG Ya-ping4(1.Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011,China;2.North China Pharmacal Coperation China;3.Hebei Medical University Shijiazhuang 050011,China;4.Hebei Science and Technology Publishing House,Shijiazhuang,050073, China );Isolation and Purification of Antitumor Component in Rhizoma Menispermi and Analysis of Its Activity[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-03
2 ZHU Jing-tong,BAI Yu ,SI Wen-xiu ,LIU Hong-xi,REN Qu-hui (NCPC Drug R&D Co,Ltd,Shijiazhuang 050015,China);Study About Anti-tumor Effect of Pulsatilla Chinensis(Bunge)Regel Extracts in Vitro[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-01
3 Wu Jinlong, Wang Liyun, Lin BoayinJiangsu provincial Anti─Epidemic and Hygienic Station, Nanjing 210009;GENOTOXIC EFFECT OF CDOP ON GERM CELL OF MALEMOUSE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1994-03
4 Wu Jinling; Shi Genyong; Chcn Xinxia and Wang Liyun(Jiangsu Provincial Anti-Epidemic and Hygienic Station,Nanjing 210009);MUTAGENICANDANTIMUTAGENICDETECTIONOFSODIUMBISELENITEINVITRO[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1996-02
5 Wang Zhijie,Huang Tieniu (Virus Research Institute,Hubei Medical University,Wuhan 430071,China);EFFECT ANALYSIS OF ANTIHERPES SIMPLEX VIRUS TYPEHSV_(-2) WITH COMBINATION OF RHIZOMA POLYGONI CUSPIDATI AND ASTRAGALUS MEMBRANACEUS[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-03
6 WANG Zhi jie,HUANG Tie niu,LIU Yan wen,YANG Zhan qiu,XIAO Hong (Virology Institute, Medical College, Wuhan University, Hubei Wuhan 430071, China);ANTI-VIRAL EFFECTS OF TOTAL POLYSACCHARIDES OF ASTRAGALUS MEMBRANACEUS ON HERPES SIMPLEX VIRUS TYPE-2[J];Journal of Anhui Traditional Chinese Medical College;2002-02
7 LI Chun yi1,REN Wen long2,LI Chang ben3,et al.1.Department of Clinical Pharmjacology,Beijing Institute for Cancer Research, Beijing 100034,P.R.China2.Department of Pharmacology,Shanghai Institute of Pharmaceutical Industry,Shanghai 200437,P.R.China3.Th;The antitumor activity of recombinant human lymphotoxin[J];CHINESE JOURNAL OF CANCER;1999-04
8 PENG Xu yang, HE Zhi ding, WU Yang Hunan Province Tumor Hospital, Changsha 410006,P.R.China;Induction of apoptosis in human colorectal carcinoma cell line SW 260 by THP[J];CHINESE JOURNAL OF CANCER;1999-06
9 LI Ping＊， ZHENG Jian, GUO Liang- jun, ZHUANG Cheng- hai Department of Oncology, the First Affiliated Hospital, Jinan University, Medical College, Guangzhou 510630， P.R.China;Concomitant Cisplatin and 5- Fluorouracil with Veinal or with Oral High- Dose Leucovorin in Treatment of Patients with Advanced Nasopharygeal Carcinoma[J];Chinese Journal of Cancer;2001-04
10 TANG Cheng wei*, TANG Li ping, WANG Chun huiDepartment of Gastroenterology,The First Hospital,Chongqing University of Medical Sciences, Chongqing 400016,P.R.China;Effects of Combination of Octreotide and Aspirin on Proliferation ofHuman Hepatocellular Carcinoma[J];Chinese Journal of Cancer;2002-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LI Jun-xin1,SHAN Bao-en2(1.Women and Children's Medical Center,Qingdao 266000,Shandong;2.Science and Research Center,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei,China);The Study of Cortex Periplocae Extract on the Differentiation of K562 Cells[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-06
2 ZHANG Ying-ying et al (College of Animal Science and Technology,Northwest A & F University, Yangling,Shaanxi 712100);Studies on Screening Compound Diluent Prescriptions with Traditional Chinese Medicine for Bull Semen[J];Journal of Anhui Agricultural Sciences;2007-10
3 DU Wu-ting et al(Key Laboratory of Environmental Science and Biodiversity Conservation of Sichuan Higher Education,College of Life Science,China West Normal University,Nanchong,Sichuan 637002);Comparison of Total Flavonoid Content in Leaves of Different Age Stems of Epimedium sagittatum[J];Journal of Anhui Agricultural Sciences;2009-06
4 XIE Qiu ling,DAI Yun,SUN Fen yong,LIN Jian, CHEN Xiao yin,ZHANG Mei ying,CHEN Xiao jia (Bioengineering Institute of Jinan University, Guangdong Guangzhou 510632,China);THE MORPHOLOGY OF MELANOMA INDUCED BY GLUCOSAMINE HYDROCHLORIDE[J];Journal of Anhui Traditional Chinese Medical College;2002-03
5 Chen Xin yi~1 Xu Li~2 Zhang Yan ming~1 Sun Tao~11 Beijing University of TCM,Beijing 100029,China2 Nanjing University of TCM,Nanjing,210029,China;Developing study on neoangiogenesis of malignant tumor[J];Oncology Progress;2005-06
6 Chen Min,Feng Li,Yang Jiguo,et al Zhejiang Chinese Medical University,Hangzhou(310053);The Research of CAMP’s Messenger Function in Disease[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-03
7 ZHAO Jun1,2 JIN RiGuang1 LUO Lu1 (1.College of Materials Science and Engineering,Beijing University of Chemical Technology,Beijing 100029;2.National Institute of Pharmaceutical Research & Development Co Ltd,Beijing 102206,China);A correlation between the anti-HIV properties of Chinese medicinal herbs and their trace element content[J];Journal of Beijing University of Chemical Technology(Natural Science Edition);2007-05
8 Luo Wenji(The First Hospital of People of Xiaoshan County; Zhejiang; The Hospital of TCM of Zhejiang Province, Hang Zhou);Experimental Research of Sophocarpidine Inducing Leukemia Cell HL-60 into Differentiation[J];China Journal of Traditional Chinese Medicine and Pharmacy;2001-05
9 FU Li-bo1,2,XU Hai-yan2,LIU Feng-lian3,YANG Yan-long1,YANG Yan-ping2(1.Basic Medical College,Jinlin University,Changchun 130021,China;2.College of Life Sciences,Changchun Teachers College,Changchun 130032,China;3.Experiment and Education Technology Center,Linyi Teachers College,Linyi 276005,China);Effects of epimedium on blood pressure in normal and stress-induced rats[J];Journal of Northeast Normal University(Natural Science Edition);2008-01
10 Fu Yan-li Xu Zhong-liang Li Yuan-jun (Harbin No.6 Pharmaceutical Factory,Harbin 150056,China);Research on Refining Process of Epimediun Flavonoids by Macroporous Resin[J];Chinese Journal of Medicinal Guide;2008-04
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Shi Jing;Lian Gang;Zhang Han;Zhang Yun Immunology Department, Institute of Basic Medical Sciences, Chinese Academy of Medical Seiences Beijing;Modification of technique for measuring cAMP Level[J];Chinese Journal of Immunology;1985-02
2 Yan Ding Shan-Tian Xin Jing-Huan Zhou Inst. Pharmac.& Toxic.27 Tai-Ping Road Beijing 100850 P.R.China;The mechanism of mouse thymus atrophy caused by Epimedium Polysaccharide.[J];Chinese Journal of Immunology;1993-03
3 Jian Zhu-han et al;c-AMP LEVELS IN LYMPHOCYTE, BLOOD PLASMA AND URINE OF PATIENTS WITH NASOPHARYNGEAL CARCINOMA[J];Tumor;1982-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved