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《Chinese Journal of Oncology》 2001-03
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β-elemene induces apoptosis of K562 lenkemic cells

ZOU Lijuan, LIU Weixian, YU Limin, et al. Second Hospital of Dalian Medical University, Dalian 116027,China  
Objective To investigate the apoptosis inducing effect of β elemene on K562 leukemia cells.Methods Hoechst 33342 and PI fluorescence staining, DNA fragmentation, electron microscopy, flow cytometry, and immunocytochemistry were used to evaluate the effect of β elemene on K562 cells.Results β elemene heatment induced the formatin of apoptotic bodies and DNA ladder. The effect was dose and time dependent. The expression of bcl 2 was decreased in β elemene treated cells as compared with the untreated control cells.Conclusion β elemene exerts its cytotoxic effect on K562 lenkenmic cells by the induction of apoptosis.
【Key Words】： elemene ? K562 cell line ? Apoptosis
【CateGory Index】： R733.7
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