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《Chinese Journal of Oncology》 2006-01
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Significance of EGFR and p-ERK expression in nasopharyngeal carcinoma

WANG Shu-sen, GUAN Zhong-zhen,XIANG Yan-qun, WANG Bo, LIN Tong-yu, JIANG Wen-qi, ZHANG Li, ZHANG Hui-zhong, HOU Jing-hui.Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China  
Objective To detect the expression of EGFR and p-ERK in nasopharyngeal carcinoma (NPC) and investigate their clinical significance. Methods Immunohistochemistry LSAB method was adopted to detect the expression of EGFR and p-ERK. Statistical analysis was performed using SPSS statistical software package (10.0) to correlate their expression with clinical characteristics and prognosis. Results Positive staining for EGFR was observed in 39 of 55 cases (70.9%). The EGFR expression was correlated with clinical stage and gender. EGFR expression was correlated with poorer overall survival (OS) and shorter time to progression (TTP). Positive staining for p-ERK was observed in 29 of 55 cases (52.7%). There was a statistically significant association between positive p-ERK expression and advanced clinical stage. Positive p-ERK expression was correlated with poorer OS, disease-free survival (DFS) and TTP. EGFR expression was correlated with the expression of p-ERK. On multivariate analysis, age over 50 years was an independent poor prognostic factor for NPC. Both EGFR and p-ERK were not independent prognostic factors for NPC. Conclusion Expressions of EGFR and p-ERK are detected in NPC. Their abnormally high expression signifies poor prognosis in NPC patients.
【Fund】: 国家“九五”科技攻关基金资助项目(969010402)
【CateGory Index】: R739.63
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