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《Chinese Journal of Oncology》 2006-09
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X-chromosomal inactivation skewing in blood cells is associated with early development of lung cancer in females

LI Gang, SU Qin, LIU Gui-qiu, GONG Li, ZHANG Wei, ZHU Shao-jun, ZHANG He-long, FENG Ying-ming, ZHANG Yu-hai. Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China  
Objective To observe the relationship between skewed X-chromosomal inactivation (SXCI) and development of lung cancer in females. Methods DNA was isolated from peripheral blood cells from patients with primary lung cancer (n = 148) and control subjects (n =289). Exon 1 of androgen receptor ( AR) gene was amplified, with its products from different alleles resolved on denaturing polyacrylamide gels and visualized by silver staining. The corrected ratio ( CR) between products from different AR alleles before and after Hpa II pretreatment was calculated. All statistical tests were two-sided. Results With CR≥10 adopted as the criterion, SXCI was found more frequently in the younger patients (≤50 years; 7. 9% ) than in the controls of the same age group (1.2%; P = 0. 046). The SXCI frequency, however, were not significantly different between the old patients ( 50 years; 4. 5% ) and the controls of the same age group (5.4% ; P=0.488). Whether taking CR≥3 or CR≥10 as the criteria, the average ages of the patients with SXCI were more than 10 years younger than those without SXCI ( P 0. 05 ) . Conclusion SXCI in blood cells is associated with early development of lung cancer in females.
【Fund】: 国家自然科学基金资助项目(30171052、30572125);; 陕西省卫生厅科研基金资助项目(02D02)
【CateGory Index】: R734.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Xia Chu, Qin Su, Li Gong, Wei Zhang, Shu-Fang Wang, Shao-Jun Zhu, Ai-Ning Li, Department of Pathology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China Qin Su, Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Ying-Ming Feng, Department of Oncology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China;Clonality of nodules of altered hepatocytes in livers with chronic hepatitis B and cirrhosis[J];World Chinese Journal of Digestology;2005-08
2 ;新世纪肿瘤防治的目标[J];Chinese Journal of Oncology;2002-03
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LI Gang~1, SU Qin~ 1,2 , ZHANG Wei~1, et al.~1Department of Pathology, ~2Department of Pathology, Cancer Hospital , Chinese Academy of Medical University and Peking Union Medical College, Beijing 100021, China; ~3Department of Oncology, TangDu Hospital, the Fourth Military Medical University, Xi'an 710038, China.;X-chromosomal inactivation skewing in blood cells in Chinese healthy females screened for the females predisposed to cancer.[J];Journal of Modern Oncology;2006-03
2 Li Gong, Wei Zhang, Ai-Ning Li, Gui-Qiu Liu, Qin Su, Department of Pathology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China Hong-Tu Zhang, Shan Liu, Yun-Tian Sun, Qin Su, Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Application of clonality analysis in diagnosis of focal nodular hyperplasia[J];World Chinese Journal of Digestology;2006-06
3 YANG Yong-jun;Research Progress on Molecular Biology and Morphological Characteristics in Precancerous Lesions of Hepatocellular Carcinoma[J];Bulletin of Chinese Cancer;2008-01
4 Ayhen·Qukuerhan;Characterization of prevalence of malignant tumors in Kazakh nationality[J];Chinese Journal of Oncology;2006-10
5 LI Chan-chan1,LI li1,BIE Meng-jie2,et al.(1.Cancer Center,Sun Yat-sen University,State Key Laboratory of Oncology in South China,Guangzhou 510060,China;2.Department of Physics,Sun Yat-sen University,Guangzhou 510275,China);Application of Fractal Dimension and Degree of Heterogeneity in Mammography to Differential Diagnosis for Breast Tumors[J];Journal of Oncology;2010-03
China Proceedings of conference Full-text Database 1 Hits
1 PAN Yongfu, ZHANG Guanqun, HAN Li Department of TCM, Huadong Hospital(Shanghai, 200040);Clinical observation of effect on life quality of 30 post-operation carcinoma of large intestine patients in the elderly by differ-zhen-determine-remedy[A];[C];2005
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 LI Gang~1, SU Qin~ 1,2 , ZHANG Wei~1, et al.~1Department of Pathology, ~2Department of Pathology, Cancer Hospital , Chinese Academy of Medical University and Peking Union Medical College, Beijing 100021, China; ~3Department of Oncology, TangDu Hospital, the Fourth Military Medical University, Xi'an 710038, China.;X-chromosomal inactivation skewing in blood cells in Chinese healthy females screened for the females predisposed to cancer.[J];Journal of Modern Oncology;2006-03
2 Zhu Yan-bo1, Wang Qi2, Xue He-sheng3, Orikasa Quaalude○41Management College, 2School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China; 3Chinese Center for Disease Prevention and Control, Beijing 100000, China; 4Toyama University, 930-0194 Japan;Preliminary assessment on performance of Constitution in Chinese Medicine Questionnaire[J];Chinese Journal of Clinical Rehabilitation;2006-03
3 ZHU Yan-bo~1 WANG Qi~1 YAO Shi-lin~2 (1.Beijing University of Chinese Medicine,Beijing 100029;2.Anhui College of Traditional Chinese Medicine);Study on the Related Influencing Factors of Yang-deficiency Constitution in Chinese Medicine[J];Journal of Traditional Chinese Medicine;2007-12
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