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Comparison total N-nitrosamides in fasting gastric juice from srbjects in high and low risk areas ror gastric cancer

Deng Dajun,Chang Yunsheng,Li Jiyou ,et al.Beijing Institute for Cancer Re-search and School of Oncology,Beijing Medical University,Beijing 100034  
Objective The status of human exposure to N-nitrosamides (NAD)is almost un-known,although they are probably carcinogenic to human stomach.This study is to elucidate the re-lationship between NAD exposure and carses of gastriccarcinomas (GC).Methods The total amount of natural NAD was detected with a photohydrolysis-TEA method(184 nmole/l,detctionlimit)in fasting gastric juicesamples from subjects aged 35~68 by fibroendoscope both in high and low risk area for GC with the same geographical and socioeconomic conditions in Shangdon Province,China.Results A)More NAD-positive samples in the high risk area (Linpu County,n=176)were observed than in the low risk area (County,n=99),the difference was significantly after age-adjustment (40.9%,p=0.0324).B)84% of samples was pH≤3 in Chongshan,whereas only 48% in Linpu (p0.001). In the acidic samples more acidic samples more NAD-positive ones in Linpu were found than in Chongshan (46.2% vs27.4%,p0.01).NAD-positive rate was higher in sam-ples with pH≥5 than those with pH≤3 only in the low but mot in the high risk area.C) NAD-posi-tive rate sas also higher in samples from subjects with chronic atrophic gastritis (CAG) with or without dysplasia than those from normal subjects and from those with superficial gastritis or CAG with intestinal metaplasia both in the high and low risk areas.ConclusionThe results suggest that human endogenous to NAD in the highrisk area for GC be higher than that in the low risk area;CAG and dysplasia may play a role in human gastric carcinogenesis by N-nitrosamides.
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