Deletion of MTS1/p16 gene in endometrial carcinoma
Zhou Chunxiao, Sun Jianheng, Lu Shixin, et al. Cancer institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021
Objective To investigate the possible relationship between deletion of MTS1/p16 gene and progression of endometrial carcinoma.Methods Thirty two primary endometrial carcinoma, 7 tumor adjacent endometrial tissue and 10 normal endometrial tissue specimens were examined for homozygous deletion of MTS1/p16 gene by polymerase chain reaction based analysis.Results Of 32 endome trial cancer specimens, 6(18.8%) showed homozygous deletion of MTS1/p16 gene. No deletion was detected in the tumor adjacent and normal endometrial tussues. Nor was it detected in well differentiated endometrial carcinoma.Conclusions Deletion of MTS1/p16 gene might contribute to the progression of endometrial carcinoma and could be served as indicator for predicting prognosis.