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Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes

WANG Xingyuan, SUN Yan, LI Weidong et al. Department of Medical Oncology, National Laboratory of Molecular Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021  
Objective To investigate alterations of fragile histidine triad (FHIT) gene and p16 gene in lung cancer. Methods Forty nine lung cancer specimens and 16 matched metastatic hilar lymph nodes of lung cancer patients were examined for abnormalities of p16 and FHIT genes by using RT PCR and RT PCR SSCP. Results Thirty two of 47(68.1%) samples of primary lung cancer and 15 of 16 (93.8%)samples of metastatic hilar lymph nodes exhibited loss of FHIT gene transcripts. In 14 of the 47 samples of primary lung cancer(29.8%), and 9 of 16 samples of metastatic hilar lymph nodes(56.3%), FHIT gene transcripts were deleted in exones 1~4. The deletion rate of p16 gene transcripts in exons 2~3 was 36.7%(18/49) in primary and 56.3% (9/16) in metastatic lymph nodes, respectively. The loss of p16 or FHIT expression did not correlate with sex, smoking, TNM stage, but was more frequently observed in poorly differentiated cancer. No mutation of FHIT and p16 cDNA was found by SSCP. Conclusions Loss of FHIT and p16 gene transcript is frequent in lung cancer and may be an early event in lung carcinogenesis. Mutations may not be the major mechanisms of p16 and FHIT gene inactivation. Lung cancer with FHIT and p16 gene alterations have more malignant phenotype and behavior.
【Fund】: 国家攀登计划项目
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Chinese Journal Full-text Database 9 Hits
1 WANG Ping1,ZHANG Qing2,WANG Zu-yi2,CHENG Ze-nong1,YU Dong-hong1,WU Shi-wu1(1.Department of Pathology,Bengbu Medical College,Bengbu 233030,Anhui;2.Central Laboratory,Affiliated Hospital of Bengbu Medical College,Bengbu 230004,Anhui,China);Expression of FHIT and p16 in Non-small Cell Lung Cancers[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-03
2 LI Dian-ming~1,LIU Chao~1,CHEN Yu-qing~1,XIA Xue-mei~1,HUANG Li-nian~1,LI Bai-qing~2(1.Department of Respiratory Diseases,Affiliated Hospital of Bengbu Medical College,Bengbu 233004;2.Department of Immunology,Bengbu Medical College,Bengbu 233003,China);Expression of survivin mRNA in lung cancer tissue and its relationship with prognosis[J];Journal of Bengbu Medical College;2005-03
3 CHANG Xiujun, YANG Sheng, ZHANG Haiqing, WANG Hui, JIANG Ying. Department of Thoracic Surgery, Tuberculosis and Thoracic Tumor Research Institute of Beijing, Beijing 101149, P.R.China;Expression of FHIT gene in precancerous lesions and primary lung cancer tissues[J];Chinese Journal of Lung Cancer;2006-04
4 GUO Xiang-yun MA Li-ya LIU Xiao-xia (Department of Occupational Disease,People's Hospital of Gansu Province,Lanzhou 730000,China);The Expressions of P53,P21~(WAF/CIP1) and Cyclin D1 in Lung Tissue of Mice Treated with Bitumen Fume[J];Journal of Environmental & Occupational Medicine;2008-02
5 HUO Xiao-dong, Li Guo-hua (Inner Mongolia Medical College, Hohhot 010059 China);THE RESEARCH PROGRESS OF BIOLOGICAL BEHAVIOUR OF PRIMARY CANCER AND METASTATIC CANCER[J];Acta Academiae Medicinae Neimongol;2005-02
6 LI Dian-ming, XIA Xue-mei, LIU Chao, CHEN Yu-qing, CAI Ying-yun. Department of Respiratory Diseases, Affiliated Hospital, Bengbu Medical College, Bengbu 233004, China;The significance of FHIT gene detection for the diagnosis of lung cancer in transbronchial biopsy tissue samples and sputum samples[J];The Journal of Practical Medicine;2008-21
7 YU Yong-chun, SUN Fen-yong, LI Zhi, LU Shao-yi, TENG Xiao-hong. "Center Laboratory, Railway Hospital Affiliated to Tongji University, Shanghai 200072, China;Relationship between aberrant FHIT transcripts and hepatocellular carcinoma[J];Chinese Journal of Hepatology;2003-09
8 CHEN Ping1, LI Jian2, YIN Kai-sheng1, YU Li-chao3 (1. Department of Respiration, the First Affilicated Hospital of Nanjing Medical University, Nanjing 210029; 2.Department of Respiration 3.Department of Chest, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001,China);Studies On the Deletion of p16 Gene in Non-small Cell Lung Cancer[J];Journal of Zhenjiang Medical College;2004-02
9 CHEN Ping,LI Jian,HANG Jian-ming,ZHAO Xi-wu,ZHANG Lan-shi(Department of Respiratory Medicine,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu 212001,China);Detection of FHIT deletion in tissues obtained by fiberoptic bronchoscopy and its diagnostic value of lung cancer[J];Journal of Jiangsu University(Medicine Edition);2006-06
Chinese Journal Full-text Database 10 Hits
1 AN Qian, DONG Xiang-yang, ZHANG Jian-jun, HUANG Jin-feng, LI Li, CHENG Shu-jun, GAO Yan-ning (Cancer Institute (Hospital), Peking Union Medical College/ Chinese Academy of Medical Sciences, Beijing 100021, P. R. China);Studies on Inactivation of p16/CDKN2 Gene in Non-Small Cell Lung Cancer[J];Chinese Journal of Cancer;2001-06
2 XIA Xue-mei 1,CHEN Yu-qing 1,CAI Ying-yun 2,LI Dian-ming 1,HU Jun-feng 1,HUANG Li-nian 1 (1.Department of Respiratory Diseases,Affiliated Hospital of Bengbu Medical College,Anhui,233004;2.Pulmonary Department,Sun Yat-sen Hospital Affiliated to Fudan University,Shanghai 200032,China);The synergic effect of survivin antisense oligonucleotide on apoptosis in lung cancer cell lines[J];Journal of Bengbu Medical College;2005-01
3 CHEN Jun, ZHOU Qinghua, QIN Yang, SUN Zhilin, SUN Zefang, WANG Yun, LI Lu, QIN Jianjun. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R.China;A study on transcript abnormalities of FHIT gene in human non small cell lung cancer[J];CHINESE JOURNAL OF LUNG CANCER;2000-04
4 WANG Yun, ZHOU Qinghua, ZHANG Shangfu, CHENG Liang, LIU Lunxu, LI Lu, WU Zhu, CHE Guowei, QIN Jianjun. Department of Thoracocardiac Surgery, West China Hopsital, Sichuan University (Former The First University Hospital, West China University of Medical Sc;Reduction of FHIT gene expression in primary lung cancer[J];Chinese Journal of Lung Cancer;2002-01
5 ZHAO Po, LU Yali, ZHONG Mei, CHEN Lezhen. Department of Pathology, Chinese General Hospital of People's Liberation Army, Beijing 100853, P.R.China;Clinicopathological analysis of loss of fragile histidine triad expression in lung cancer[J];Chinese Journal of Lung Cancer;2002-05
6 Chen Honglei,Diao Luming,Chen Deji,et al Department of Pathology, School of Medicine, Wuhan University, Wuhan 430071,China;Deregulation Significance of Rb Tumor Suppression Pathway during Carcinogenesis of Lung Cancer in Wistar Rats[J];Journal of Hubei Medical University;2003-03
8 XIAN Lei, WANG Jun, JIANG Guan-chao, WANG Dan-lei, LIU Jun, LI Jian-feng (Dept. of Thoracic Surgery, People's Hospital , Peking University, Beijing 100044,China);Study of mRNA Expressions of FHIT Genes in Patients with Non-small Cell Lung Cancer[J];Academic Journal of Kunming Medical College;2005-02
9 CHEN Yuqing,CAI Yingyun, LIU Limin.Department of Pulmonary Medicine, Affiliat ed zhongshan Hospital of Fudan University,Shanghai 200032,China;Clinical significance in diagnosis with measuring the altera tion of p53,K-ras and p16 genes in lung cancer[J];Journal of Clinical Internal Medicine;2003-05
10 LIANG Qun-ying,GUO Rui-zhen,TANG Wen-tai,et al.Deptment of Pathology,Zunyi Medical College,Zunyi 563003,China;Expression of Survivin Gene and its Relationship with Expression of p53,Bcl-2 Gene in Nasal NK/T Cell Lymphomas[J];Journal of Qilu Oncology;2003-04
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 YUAN Lin,SHEN Shi qiang,XIONG Chen long,et al.Department of General Surgery,Renmin Hospital of Wuhan University,Wuhan,430060,China;Study of the FHIT gene in hepatocellular carcinoma[J];Journal of Abdominal Surgery;2004-04
2 HUO Xiao-dong,SUN Qin-nuan,LI Guo-hua (Department of Nephrology,central Hospital of Baotou,Baotou 014040 China);EXPRESSION AND CLINICAL SIGNIFICANCE OF SURVIVIN,CASPASE-3,GST AND PGP IN NSCLC[J];Acta Academiae Medicinae Neimongol;2006-04
3 GUO Wen-feng.Center Hospital of Baotou City,Inner Mongolia 014010,China;Expression and clinical significance of Caspase-3 GST Pgp in non-small-cell lung cancer[J];Journal of Clinical Pulmonary Medicine;2010-04
4 LIAO Xiu-qing,YU Shi-cang,WANG Chao-yong.Department of Respiratory Medicine,ChongqingFuling Central Hospital,Fuling,408000,Chongqing,CHINA;Microsatellite instability on 3p in the diagnosis of early lung cancer.[J];Hainan Medical Journal;2010-08
5 YIN Xiaomin1,WEN Chunyan2,HAN Yuling2,GAO Yijun2,TANG Zhangui3(1.Department of Stomatology,Xiangya Hospital,Central South University,Changsha,410078;2.Department of Stomatology,Second Xiangya Hospital,Central South University,Changsha 410011;3.Department of Oral and Maxillofacial Surgery,Xiangya Hospital,Central South University,Changsha 410078,China);Expression of FHIT and MDM2 in oral submucous fibrosis and canceration tissues[J];Journal of Central South University(Medical Science);2010-06
6 WANG Qi1,MA Xin-bo2,CAI Wen-hui2,WANG Ya-xian2(1.Department of Immunology,Qiqihaer Medical College,Qiqihaer 161042;2.Department of Microbiology and Immunology,Heilongjiang University ofChinese Traditional Medicine,Harbin 150040,China);Guizhi Fuling Wan's effect on the expression of P21~(waf/cip) in bearing tumor mice[J];Journal of Xi'an Jiaotong University(Medical Sciences);2009-02
7 HAN Xiao-hong1,SHAO Shi-he1,XU Hua-xi1,XUE Yan-jun 1,LIU Yan-fang2,DENG Yi-mai2,CHEN Wei-wei2,CAO Juan2(1.School of Medical Science and Laboratory Medicine,Jiangsu University,Zhenjiang Jiangsu 212013;2.School of Medical Science and Laboratory Medicine,Jiangsu University,04 Grade,Zhenjiang Jiangsu 212013,China);Inhibition mechanism of sodium selenite on SW-111C cells[J];Journal of Jiangsu University(Medicine Edition);2008-06
8 WANG Xiao-li, CHEN Chun, FEI Su-ding (1.Ningbo College of Health Sciences, Ningbo 315100, China; 2.Fujian Medical University Union Hospital, Fuzhou 350001, China);Expression and Significance of Fragile Histidine Triad (FHIT) and Survivin in Non-small Cell Lung Cancer[J];Journal of Oncology;2009-12
9 ZENG Zhihui(Department of Respiratory Medicine,Yuanjiang People's Hospital,Yuanjiang 413100,China);FHIT expression and the relationship with expressions of Survivin and Ezrin proteins in non-small cell lung cancer[J];China Medical Herald;2010-20
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