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《Chinese Journal of Plastic Surgery and Burns》 2002-01
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Experimental studies on histocompatibility of three bio-derived bones

YANG Zhiming,LI Yanlin,XIE Huiqi,QIN Tingwu,HUANG Fuguo.Department of Orthopedic Surgery,the First University Hospital,West China University of Medical Sciences,Chengdu 610041,China\;  
Objective\ To study the histocompatibility of three bio derived bones. Methods\ After treatment with different physical and chemical method, three bio derived bones, the composite fully deproteinized bone (CFDB), partially deproteinized bone (PDPB) and partially decalcified bone (PDCB) were implanted into rabbits. The toxicity, immune response and subperiosteum osteogenesis of CFDB、PDPB and PDCB were studied through gross observation, serum antibody measurement, evaluation of local cellular immune response and HE staining. Results\ The study showed that CFDB, PDPB and PDCB had no toxicity. They could conduct peripheral tissue to grow into them and had no harmful effect on subperiosteum osteogenesis. They could also promote cartilage and osteoid tissue derived from periosteum to calcify to new bone, and combine with the peripheral bone. The degree of immune response caused by them was in the sequence of PDCB〉PDPB〉CFDB. Conclusions\ The three bio derived bones, CFDB, PDPB and PDCB have good histocompatibility.
【Fund】: 国家重点基础研究发展规划 (973 )组织工程的基本科学问题资助 (G1990 5 43 0 8) ;; 国家自然科学基金重点项目资助(3 983 0 10 0 )
【CateGory Index】: R318.08
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