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《Journal of Pathogen Biology》 2015-06
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Bioinformatic analysis of the rhoptry protein 12 of Toxoplasma gondii

GUO Ling-ling;WANG Chun-miao;ZHANG Jin-shun;ZHANG Xiao-lei;JIA Xiao-hui;JIANG Wen-jing;LIU Nan;Hebei North University,Institute of Pathogen Biology and Immunology;  
Objective The bioinformatic characteristics of the rhoptry protein 12 of Toxoplasma gondii were analyzed using bioanalytical software online.This work should lay the foundation for future research into the ROP12 gene. Methods The biological features of the TgROP12 protein including,its physical and chemical properties,secondary structure,domains,and epitopes,were analyzed using software online such as ProtParam,SOSUI,SOPMA,TMHMM,MotifScan,SYFPEITHI,DNAMAN,and DNASTAR. Results The TgROP12 protein consists of 236 amino acids and has the following characteristics:a molecular formula of C1125H1786N308O360S3;a molecular mass of 25.48ku;a theoretical isoelectric point of 4.53;and signal peptide and transmembrane regions.Beta turns accounted for 7.20% of the secondary structure of the TgROP12 protein while random coils accounted for 44.92%.There were 8regions with a high level of hydrophilicity(critical value:2.0)and 10 regions with a high level of surface accessibility(critical value:1.9).The TgROP12 protein contains 6conserved regions and 6post-translational modification sites.The TgROP12 protein also contains 9Bcell epitopes and 6Tcell epitopes. Conclusion The TgROP12 protein has good immunogenicity and may be a candidate for potential vaccines.
【Fund】: 河北北方学院校级重大课题(No.ZD201312)
【CateGory Index】: R382.5
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