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《Zhejiang Journal of Traumatic Surgery》 2008-03
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Changes in levels of cerebrospinal fluid TNF- α、IL- 6 in patients with acute brain trauma

LU Chuan, SUN Jun, CHEN Xiandong, et al. Wenzhou Second People's Hospital, Wenzhou 325000, China  
Objective studying the changes in the levels of cerebrospinal fluid tumor necrosis factor alpha(TNF- α) and interleukin- 6 (IL- 6) and their clinical significance in 51 patints with acute brain trauma in the different periods. Methods The relationship between the severity of brain injury and the levels of cerebrospinal fluid TNF- α, IL- 6 was analyzed in 51 patients with acute brain trauma. The data was headled dy statistics. Results Compared with the control group, the levels of cerebrospinal fluid IL- 6 on the 1st, 3rd, 7th, and14th day after brain trauma was significantly elevated; The levels of IL- 6 in the patients with severe traumatic brain injury were significantly higher than that in the patients with mild and moder- ate injury (P0.01). In the mild group, the level of IL- 6 was elevated in the early phase and decreased in the later phase; in the moderate group, closed to normal in 14th day after trauma, in the severe group still remained high level. This study discovered the levels of cerebrospinal fluid TNF- αafter trauma were significantly higher, maybe express in the earlier period after brain trauma and recover to normal quickly; didn't create the second peak corresponding to the peak of brain edema or heighten persistently. Conclusion With regard to make clinical diagnosis, judge severity of brain trauma, contain inflammatory reaction with various degrees of brain trauma in certain period, and improve the treatment of brain trauma; monitoring the levels of cerebrospinal fluid IL- 6 after brain trauma has great significance, and monitoring the levels of cerebrospinal fluid TNF- αafter brain trauma has less value than the levels of IL- 6
【CateGory Index】: R651.15
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