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《Chinese Journal of Primary Medicine and Pharmacy》 2006-12
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Clinical investigation on the immune state of patients with hepatic cirrhosis and primary hepatic carcinoma

JIANG Jing.Department of Gastroenterology,The Second Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116027,China  
Objective To study the immune state and correlated strategy of patients with hepatic cirrhosis and primary hepatic carcinoma.Methods 17 patients with hepatic cirrhosis and 8 patients with primary hepatic carcinoma(PHC) in our hospital were collected since 2002.The indexcs of immune function were detected in all patients and some were re-examined.Results It was found that although the immune index varied in patients suffering from severe liver diseases,some regularities were shown as follows:(1)CD4 and CD4/CD8 in T lymphocyte subset declined markedly(P0.05) and CD8 was suppressed.(2)The number of T lymphocyte subset and NK cell decreased in cirrhotic patients,cirrhotic patients with hepatic encephalopathy and patients with PHC.The most significant descendent tendency was shown in patients with PHC compared with cirrhotic patients.(3)The number of T lymphocyte subset showed positive relation with that of NK cells and negative relation with humoral immune reaction(plasma globulin).Conclusion The treatment of PHC with interleukin-2 has shown that the level of CD4 could be suitable index on drug efficiency and interleukin-2 therapy can adjust severe disorder of immune system.
【CateGory Index】: R575.2;R735.7
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