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《Chinese Journal of Critical Care Medicine》 2001-03
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Changes of cyclooxygenase isoenzyme and effects of meloxicam in acute lung injury induced by lipopolysaccharide

WANG Jin-sheng, CHEN Zheng-tang, QIAN Gui-sheng, et al. Institute of Respiratory Disease, Xinqiao Hospital, third Military Medical University, Chongqing 400037, China  
Objective To investigate the changes of cyclooxygenase(COX) isoenzyme and effects of meloxicam(MEL) in acute lung injury(ALI).Methods 96 Wistar rats were randomized into control, lipopolysaccharide(LPS) stimulated, MEL treated group, the changes of COX-1 and COX-2 protein were examined with immunohistochemistry, the levels of PGE 2 (served as COX activity indireactly) were measured by radio-immunoassay.Results No marked difference of COX-1 protein was found in both LPS stimulated group and control group ( P 0.05), but COX-2 protein expression and levels of PGE 2 in LPS stimulated group were rapidly increased and significantly higher than those in control group ( P 0.01). The peak value of COX-2 mRNA and protein in ALI was at 4 h and 6 h, respectively. No significant changes in COX-1 and COX-2 protein expression were found between MEL group and LPS treated group ( P 0 05), but the levels of PGE 2 in MEL treated group were markedly lower than those in LPS treated group ( P 0.01).Conclusion Excessive expression of COX-2 and inappropriate activation of COX-2 may play an important role in the pathogenesis of ALI with LPS-induced, selective inhibition of COX-2 activity in MEL treated may down-regulate the inflammatory response in ALI.
【Fund】: 国家自然科学基金!资助 (№ 3980 0 0 6 4)
【CateGory Index】: R363
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