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《Chinese Journal of Critical Care Medicine》 2003-03
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Study on the coronary reperfusion and changes of serum creatine kinase in acute myocardial infarction with microvascular obstruction

MENG Qing-yi,YANG Xiao-qiu,QIAN Yuan-yu,et al.Department of Emergency Medicine,Chinese PLA General Hospital,Beijing 100853,China  
Objective To evaluate the serum creatine kinase(CK) and MB isoenzyme characteristics in acute myocardial infarction(AMI)with microvascular obstruction (MO).Methods The coronary reperfusion,serum CK and MB isoenzyme activities were measured in 10 patients with AMI and MO detected by contrast-enhanced magnetic resonance imaging and compared with 12 simple AMI cases without MO.Results There was less coronary reperfusion frequency in AMI patients with MO compared with simple AMI group(coronary angiogram TIMI 3:after AMI 0 vs.41.7%,P=0 030;before MRI 50.0% vs.75 0%,P=0 173).The peak activities of CK and MB isoenzyme in MO group were significantly higher than that of simple AMI group[CK:(1 411 1±928 3)U/L vs.(845 2±837 1)U/L,P=0 050;MB:(11 7±6 1)%vs.(7 2±3 4)%,P=0 043] The frequency of CK peak activity not less than 1 000 U/L in MO group was 70%(7/10),and was higher than that in non-MO group(33 3%,4/12,P=0 194) The ratio of CK peak over infracted size (larger than 5 000 U/L) in MO group was less than non-MO group (20 0%,2/10 vs.58 3%,7/12;P=0 072).Conclusion Higher cardiac enzyme peak and less coronary reperfusion frequency were found in MO patients and cardiac enzyme release might be decreased around the infarction area.
【CateGory Index】: R542.22
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