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《Chinese Journal of Critical Care Medicine》 2019-05
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Effect of atorvastatin calcium on serum GFAP,TNF-α,NSE levels and nerve function in the treatment of acute stroke

Zhang Dong-lan;Cao Li-ping;Huang Yuan;Shao Yong;Department of Encephalopathy,the First Affiliated Hospital,Guizhou University of Traditional Chinese Medicine;  
Objective To investigate the effect of atorvastatin calcium on serum glial fibrillary acidic protein(GFAP),tumor necrosis factor-α(TNF-α),neuron-specific enolase(NSE)levels and nerve function in the treatment of acute stroke.Methods A total of 82 cases of acute ischemic stroke treated in nerve department of internal medicine in our hospital were selected and divided into two groups by random number table method.Control group of 41 cases were treated with conventional therapy,and the experiment group were treated with atorvastatin calcium on the base of the control group.Serum inflammatory factor index,brain injury related protein levels,the neurological function score,the clinical efficacy and the occurrence of adverse reactions were compared before and after treatment.Results The effective rate of treatment in the observation group(92.68%)was significantly higher than that in the control group(75.61%),and the difference was statistically significant(P0.05).Over treatment,the serum TNF-α level in the observation group was significantly lower than that in the control group[(16.23 ±2.23)ng/L vs.(27.83 ±3.91)ng/L,P0.05],and the IL-6 level in the observation group was significantly lower than that in the control group[(7.25 ±1.03)pg/mL vs.(13.12 ±1.64)pg/mL,P0.05].The level of IL-1β in the observation group was significantly lower than that in the control group[(13.24 ±1.77)pg/mL vs.(24.16 ±3.25)pg/mL,P0.05].CRP level in the observation group was significantly lower than that in the control group[(3.97 ±0.55)mg/L vs.(6.76±0.86)pg/mL,P0.05].The serum levels of NSE,GFAP and S100β in the observation group were significantly lower than those in the control group[NSE:(14.25 ±2.03)ng/mL vs.(23.13±3.24)ng/mL; GFAP:(4.26 ±0.58)ng/mL vs.(7.56 ±1.07)ng/mL;S100β:(20.96 ±2.57)ng/L vs.(27.13 ±3.09)ng/L],the difference was statistically significant(P0.05).The NIHSS score of observation group(12.45 ±1.08)was significantly lower than that of control group(15.63 ±2.23).The BI score and the FMA score in the observation group were significantly higher than those in the control group after treatment[BI score:(61.16 ±8.34)vs.(52.14 ±7.05); FMA score:(48.12 ±6.11)vs.(36.56 ±5.22)].After treatment,the expression of caspase-3 mRNA(0.37 ±0.06)and Bax mRNA(0.42 ±0.68)in the observation group was significantly lower than that in the control group,and the mRNA expression of Bcl-2(2.91 ±0.68)was significantly higher than that of the control group(P0.05).Conclusion Atorvastatin calcium can reduce serum GFAP,TNF-α,NSE levels in patients with acute stroke,inhibit apoptosis of brain cells,improve neurological function,and the curative effect is remarkable.
【CateGory Index】: R743.3
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【Co-citations】
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1 Feng Tao;Department of Neurology,the First Affiliated Hospital of Nanyang Medical College;;Effect of early rehabilitation therapy on ADL,NIHSS,GST in patients with acute cerebral infarction[J];中国基层医药;2019-15
2 Zhang Dong-lan;Cao Li-ping;Huang Yuan;Shao Yong;Department of Encephalopathy,the First Affiliated Hospital,Guizhou University of Traditional Chinese Medicine;;Effect of atorvastatin calcium on serum GFAP,TNF-α,NSE levels and nerve function in the treatment of acute stroke[J];中国急救医学;2019-05
3 Peng Yue;Liu Huiqin;Wang Bing;Department of Neurology,Henan Provincial People's Hospital;;Mild hypothermia combined with intravenous thrombolytic therapy can improve cognitive functioning and stress response after cerebral infarction[J];中华物理医学与康复杂志;2019-03
4 Li Jinyi;Li Chunlei;Nanyang Central Hospital;;Effects of edaravone combined with hyperbaric oxygen on plasma β-endorphin,GnRH,N-terminal pro-brain natriuretic peptide and copeptin in patients with acute intracerebral hemorrhage[J];临床心身疾病杂志;2019-02
5 Li Kunying;Chen Xiaoli;Li Yancun;School of Health,Wuhan University;Department of Rehabilitation Medicine,the Second Affiliated Hospital of Xi'an Jiaotong University;;Analysis of related factors of cognitive rehabilitation in patients with aphasia after cerebral infarction[J];中华现代护理杂志;2019-04
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10 Yan LIU;Yu-lin SONG;Dan ZHOU;Fu-ding ZHANG;Department of Epidemiology, School of Public Health, Medical College of Soochow University;Department of Neurology, Changda Hospital;;Relationship of albumin and globulin levels with short-term prognosis in acute ischemic stroke patients[J];中国现代医学杂志;2015-21
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1 WANG Xin, WANG Yongjun, LIU Zheng, et al. Department of Rehabilitation, Hebei Province People's Hospital, Shijiazhuang 050071;Comparative study in validity and reliability of four stroke scales[J];中华物理医学与康复杂志;1999-03
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