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《Journal of Zhangjiakou Medical Collage》 2000-01
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Analysis of TIL in RCC by immunohistochemical technique and study on relationship between TIL and prognosis of RCC

Ma Jianguo  
Purpose To get a comprehensive understand of antitumor immune state and relationship between TIL and prognosis of renal cell carcinoma (RCC). Methods: Employing immunohistochemical technique and monoclonal antibody, the composrtion, distribution and activation of TIL in RCC were studied in situ, the mam surface markers studied on TIL were CD3,CD4,CD8 antigens and CD25 and HLA - DR antigens , which could show the activation of T lymphocytes. Results: (1) The main part of TIL in RCC was T lymphocyte (CD:+), and among these percentage of CD8+ lymphocyles were significantly higher than that of CD4 + ones, the level of T - TIL in RCC and its CD4+/CD8+ ratio were negatively related to the level of malignity of RCC. (2) In situ, there were activated TIL to some extend. (3) TILs in RCC were distributed scatteredly in tumor tissues in situ. Conclusions: TIL in RCC was negatively related lo clinical stages of RCC. The quantitative study of TIL might be of objective standard in the prognosis of RCC- Studying TIL of RCC in situ can help us understand ami - tumor immunoreaction of RCC
【CateGory Index】: R737.11
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