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《Acta Agriculturae Zhejiangensis》 2019-02
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Effect of multi-strain co-fermented feed on anti-Salmonella infection in broilers

LIU Jiangying;ZHU Jianjin;JIANG Rong;LIU Ziwei;School of Food Science and Technology,Jiangnan University;Wuxi Sanzhi Biological Technology Co.,Ltd.;  
To investigate the effect of multi-strain co-fermented feed on resisting Salmonella infection in broilers,50 one-day-old broilers were randomly divided into 5 groups and were fed with different feeds: control group( basal diet+ 10% unfermented feed),model control group( basal diet + 10% unfermented feed),antibiotic control group( basal diet + 10% unfermented feed + 20 mg·kg~(-1) colistin sulfate),5% fermented group( basal diet + 5% unfermented feed + 5% fermented feed),10% fermented feed( basal diet + 10% fermented feed). Oral administration of400 μL Salmonella( 1 × 109 CFU·m L~(-1)) for two days except the control group when the broilers were 13 days old,the control group was given equal volume of sterile water. The broilers were slaughtered at the age of 15 days. Serum levels of pro-inflammatory cytokines( IL~(-1)β,IL-6,TNF-α),endotoxins( LPS) and D-lactic acid( D-LA) were measured. Got colon for HE staining was to observe the shape of colon and got cecum mucosa was to determine the m RNA expression of TLR4 pathway key signaling molecules. The results showed that salmonella infection resulted in a significantly increase level of serum pro-inflammatory cytokines( IL~(-1)β,IL-6 and TNF-α). The m RNA expression of TLR4 signal pathway key signaling molecules( TLR4,MyD88,TRAF6,NF-κB) increased significantly. The level of serum LPS and D-LA increased significantly. While the indexes of antibiotic control group,5% fermented group,and 10% fermented group were improved to some extent,indicating that the multi-strain co-fermented feed can ameliorate the intestinal inflammation and intestinal barrier destruction that caused by Salmonella infection. The effect was close to 20 mg·kg~(-1) colistin sulfate.
【Fund】: 国家自然科学基金(31201805)
【CateGory Index】: S831.5
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【Citations】
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1 LIU Xiang,LIN Man-peng,DING Yuan-wei,YANG Tao,LIN Hong(The Second Affiliated Hospital of Guangzhou Medical College,Guangzhou, Guangdong 510260,P.R.China);Role of toll-like receptor 4 in probiotic treatment of Hp infected mice[J];中国现代医学杂志;2011-01
【Co-citations】
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1 WANG Li;Department of pharmacy, The First Affiliated Hospital of Henan University of Science and Technology;;Pharmacological analysis of intestinal probiotics and medication safety investigation in adjuvant treatment of intractable Hp infection[J];中国现代药物应用;2015-02
2 ZHANG Lian,ZHOU Yu-ping*,LIU Guang-wei(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China);Therapeutic Effects of Astragalus Saponin on Rats with Atrophic Gastritis and MyD88,TLR4 Receptor[J];中国实验方剂学杂志;2013-02
3 ZHANG Ling1 YANG Caimei1 CAO Guangtian1 XIAO Yingping1 ZENG Xinfu2(1.College of Animal Science,Zhejiang University,Hangzhou 310029,China;2.Zhejiang Future Bio-Technology Co.,Ltd.,Hangzhou 310030,China);Toll-Like Receptors and Immune Function of Probiotics[J];动物营养学报;2013-01
4 @JIANG Zhen$Medical College of Qinghai University!Xi ning 810001,China @FAN Zhong-lin @WANG Xue-hong;Clinic study of probiotics combined with quadruple therapy for eradication of Helicobacter pylori associated gastritis[J];中国实用医刊;2013-09
【Secondary Citations】
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1 ZHANG Gui-ying, JIANG Li (1.Department of Gastroenterology, Xiangya Hospital of Central South University Hunanchangsha 410008, P.R.China; 2.);Study on relationship between Fas and NF-κB in helicobacter pylori-related gastric ulcer tissue[J];中国现代医学杂志;2007-24
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