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《Acta Agriculturae Zhejiangensis》 2019-02
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Determination of related substances and content of oxyclozanide suspension by high performance liquid chromatography

BAI Yubin;ZHANG Jili;ZHU Jianmin;SU Wenjie;DONG Zhen;ZHOU Xuzheng;ZHANG Jiyu;Lanzhou Institute of Husbandry and Pharmaceutical Science,Chinese Academy of Agricultural Sciences;Changzhou Yabang-QH Pharmachem Co.,Ltd.;  
In order to detect the content and related substances of oxyclozanide suspension,a new method using high performance liquid chromatography( HPLC) was established. Content determination was carried out using Hypersil BDS C18( 150 mm × 4. 6 mm,5 μm) column and 0. 1% phosphoric acid water-method( volume ratio = 38∶ 62) as mobile phase,column temperature was 25 ℃,and determination wavelength was 300 nm. Related substances was carried out using Inert Sustain Swift C18( 150 mm × 4. 0 mm,5μm) column,mobile phase,detection wavelength and column temperature were the same as the content determination method. The results showed that liner range of content determination of oxyclozanide suspension were 34. 01~(-1)04. 35 μg·m L~(-1)( R~2= 1. 000),and average recovery was100. 1%. The liner range of 2-amino-4,6-dichlorophenol hydrochloride and 3,5,6-trichlorosalicylic acid were0. 51-20. 4 μg·m L~(-1)( R~2= 0. 996,1. 000,respectively),and average recovery were 110. 3% and 98. 6%,respectively. It showed that the method was convenient,simple and accurate,and could simultaneously determine the content and related substances of oxyclozanide suspension,and provided standards for quality control of the product.
【Fund】: 国家科技支撑计划(2015BAD11B01-01);; 国家肉牛牦牛产业技术体系药物开发与临床用药岗位(CARS-37)
【CateGory Index】: S859.795
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Chinese Journal Full-text Database 6 Hits
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