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《Chinese Journal of Parasitology and Parasitic Diseases》 2008-01
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Experimental Treatment Using Combined Fructus psoraleae and Dihydroartemisinin in Mouse Cryptosporidiosis

CHEN Yu-feng1, QIN Yuan-hua1, ZHENG Li-li1, DAI Xiao-dong1, REN Yi-xin1, NIE Da-ping2, CUI Yu1(1 Department of Parasitology, Dalian Medical University, Dalian 116027, China; 2 Clinical Laboratory, The 2nd Affiliated Hospital of Dalian Medical University, Dalian 116023, China)  
A combination of Fructus psoraleae (3.4 g/kg) and dihydroartemisinin (60mg/(kg·d)) was used for 7 d in mice infected with Cryptosporidium parvum infection induced by oral administration of dexamethasone. The results indicated that number of Cryptosporidium parvum oocysts in feces, proportion of CD4+, CD3+ T lymphocytes in blood, serum IFN-γ, and nitric oxide (NO) content in intestinal tissue were all higher than those of infected control group (P0.01). The pathogenic change in intestine of treated mice was lighter than that of infected control. It is indicates that the combination of Fructus psoraleae and dihydroartemisinin is effective to mice cryptosporidiosis probably through up-regulating serum IFN-γ, proportion of CD4+ and CD3+ T cells and NO concentration in intestine.
【Fund】: 辽宁省教育厅科学研究计划资助项目(No.2004D103)~~
【CateGory Index】: R259
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