Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Zhejiang University(Medical Sciences)》 2006-01
Add to Favorite Get Latest Update

Viraemia and extraintestinal involvement after rotavirus infection

HUANG Xiao-lei,CHEN Jie,YU Yan-ping,et al(The Affiliated Children's Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China)  
Objective: To study the incidence of viraemia and extraintestinal organ damage in children with acute rotavirus(RV) gastroenteritis.Methods: Eighty-three children with acute rotavirus gastroenteritis were hospitalized from October 2002 to March 2003,whose blood and fecal samples were obtained on admission.Rotavirus RNA(encoding the VP7 outer capsid protein) were detected in blood and fecal samples by nest reverse transcription-polymerase chain reaction(RT-PCR).According to the result of blood RV-RNA,the patients were divided into RV-RNA positive group and RV-RNA negative group.The differences between these two groups in the severity of gastroenteritis and extraintestinal organ damage were analyzed.Results: Eighty-two of 83 stool samples from the children with rotavirus infection were positive for rotavirus RNA.Sixteen of 83 blood samples were positive for rotavirus RNA with a positive rate of 19.3%.The nucleotide sequence of cloned cDNAs,resembling part of the VP7 gene,was identical from paired blood and fecal samples.There were no significant differences between blood RV-RNA positive group and blood RV-RNA negative group in the rate and degree of fever,diarrhea,dehydration,metabolic acidosis,hypokalemia and myocardial damage(P0.05);while the incidences of liver damage,rash,lower respiratory tract infection and the central nervous system involvement in the blood RV-RNA positive group were significantly higher than those in the blood RV-RNA negative group(P0.05).Conclusion: Viraemia is present in the children with acute rotavirus gastroenteritis.Viraemia might be an important mechanism by which rotavirus spread to the extraintestinal sites resulting in organs damage.
【Fund】: 浙江省卫生厅专项资助科技项目(编号20012X010)
【CateGory Index】: R725.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 6 Hits
1 ;Rotavirus Gastroenteritis Accompanied by Damage of Central Nervous System[J];International Journal of Pediatrics;2007-04
2 CHEN Jun-hua,XIE Yuan-yuan,ZHU Chao-min,LIU Zuo-yi(Department of Infectious Disease,Children's Hospital,Chongqing Medical University,Chongqing 400014,China);Extraintestinal lesions caused by rotavirus:An experimental study on suckling mice[J];Acta Academiae Medicinae Militaris Tertiae;2009-15
3 Yuan Baoli Xiong Wei Department of Pediatrics,the Second Affiliated Hospital of Guangzhou Medical College (Guangzhou 510260);A Clinical Study of Extraintestinal Involvement after Rotavirus Enteritis in 65 Infants[J];Shaanxi Medical Journal;2008-01
4 ZHANG Sheng,ZHOU Tao,FU Si-mao,et al.Department of Pediatrics,Zhongshan Boai Hospital Affiliated to Nanfang Medical University,Zhongshan 528403,China;Siginificance of Detection of Serum and CSF Interleukin in Children with Rotavirus Enteritis Combined with Benign Convulsions[J];Chinese General Practice;2010-32
5 ;Clinical analysis of 93 cases of rotavirus enteritis with parenteral manifestations[J];Chinese Medical Digest(Pediatrics);2007-05
6 WAN Xiaohua,LIU Jun(Department of Pediatric,Maternity and Child Care Centers of Guixi,Jiangxi Province,Guixi 335423,China);Rotavirus enteritis with benign convulsions children IL-6,IL-8 of determination and significance[J];China Modern Medicine;2011-01
Chinese Journal Full-text Database 10 Hits
1 LI Jun, XU Ling-Fen, SUN Mei, LI Qiang, GAO Hong, JIANG Wei-Guo. Department of Pediatrics, Second Affiliated Hospital of China Medical University, Shenyang 110004, China;Protective effects of recombinant intestinal trefoil factor against intestinal injuries induced by endotoxin in young rats[J];Chinese Journal of Contemporary Pediatrics;2006-05
2 CHEN Jun-hua1,XIE Yuan-yuan1,LING Hua2,LIU Zuo-yi1(Department of Infection and Gastroenterology,Children's Hospital,Chongqing Medical University,Chongqing 400014;Chongqing Center for Disease Control and Prevention,Chongqing 400042,China);On pathogenesis of rotavirus diarrhea in suckling mouse[J];Acta Academiae Medicinae Militaris Tertiae;2007-12
3 YAO Ying-min1, OU Qiao-qun1, CHEN Yao2 Department of Pediatrics, Nanfang Hospital1, School of Biotechnology2, Southern Medical University, Guangzhou 510515, China;Ultrastructural changes of the extraintestinal organs of newborn mice with human rotavirus infection[J];Journal of Southern Medical University;2006-09
4 XU Yuan-min,TIAN Jie,ZHONG Jia-rong,et al(Children's Hospital,Chongqing University of Medical Sciences,Chongqing 400014,China);Clinical features of rotavirus enteritis combined with viral myocarditis and its therapeutic analysis[J];Journal of Pediatric Pharmacy;2006-02
5 ;Progress in the Pathogenesis of Intestinal and Extra-intestinal Rotavirus-associated Disease[J];Foreign Medical Sciences Section of Pediatric;2005-06
6 ;Research Progress of Interaction Between Rotavirus and Enterocyte[J];International Journal of Pediatrics;2006-03
7 ;Rotavirus Gastroenteritis Accompanied by Damage of Central Nervous System[J];International Journal of Pediatrics;2007-04
8 Lu Zhifang,Tao Hong,Qian Shenghua Nanjing First Hospital affiliated to Nanjing Medical University,Nanjing,210006,China;Clinical Observation of Smecta Curing Rotavirus Enteritis of Children[J];Journal of Medical Forum;2003-16
9 ZHANG Yucai, ZHANG Yuming,XU Liang,TANG Dinghua. Intensive Care Unit ,Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200040,China;Septic shock and multiple organ dysfunction syndrome from gastroenteritis in children[J];Chinese Journal of Emergency Medicine;2006-06
10 HUA Ying,LIU Wei,CHEN Shun- nian,XU Chun- di . Department of Pediatrics,Ruijin Hospital Affiliated to Medical College,Shanghai Jiaotong University,Shanghai 200025,China;Clinical observation of esomeprazole therapy for gastro- oesophageal reflux disease in children[J];The Journal of Clinical Pediatrics;2006-08
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 CHEN Bo,XIE Yong-wu,ZHENG Rui-feng(Zhuhai Maternal and Child Health Caring Hospital,Guangdong Zhuhai 519000,China);166 Cases of Gastroscopy and Analysis of Chronic Gastritis,Chronic Duodenitis and Peptic Ulcer in Children[J];Hebei Medicine;2008-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved