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《Zhejiang Medical Journal》 2004-07
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The extract of common turmeric induces apoptosis of gastric carcinoma cell line SGC-7901

XU Yi, Lu Bin, DING Zhishan, et al. Department of Gastroenterology, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310006, China  
Objective To examine whether the extract of common turmeric (Wenyujin) induce apoptosis and inhibit growth of gastric carcinoma cell line SGC-7901 in vitro. Methods Common turmeric was extracted by water, petroleum ether and ethanol. The extract of common turmeric was added to the medium of gastric carcinoma cell line SGC-7901 cultured in vitro. The proliferation of cells was detected by MTT test and direct counting method. Cell apoptotic index was examined by flow cytometry analysis and cell morphology was observed under oil and electron microscopy respectively. Results When compared with controls, tumor cell growth was significantly inhibited by extract of common turmeric decocted by water, petroleum ether and ethanol. The MTT test showed the inhibition rate was 34.4%, 49.4%和73.1% respectively. Apoptotic peak was found in cells treated with extract of common turmeric decocted by petroleum ether and ethanol. Conclusion Extract of common turmeric decocted by water, petroleum ether and ethanol inhibited growth of human gastric carcinoma cell line SGC-7901 in vitro. Apoptosis is one of the mechanisms of proliferation inhibition of tumor cells.
【CateGory Index】: R735.2
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