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《Journal of Zhenjiang Medical College》 2004-02
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Studies On the Deletion of p16 Gene in Non-small Cell Lung Cancer

CHEN Ping1, LI Jian2, YIN Kai-sheng1, YU Li-chao3 (1. Department of Respiration, the First Affilicated Hospital of Nanjing Medical University, Nanjing 210029; 2.Department of Respiration 3.Department of Chest, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001,China)  
Objective: To investigate the deletion of p16 gene in Chinese patients non-small cell lung cancer (NSCLC) and the role of the p16 gene as a tumor suppressor gene in the genesis of chinese NSCLC. Methods: Reverse transcription polymerase chain reaction(RT-PCR) was used to detect the deletion at p16 gene exons 1-2 in 31 patients with NSCLC. Results: The deletions of p16 gene were found in 26 of 31 NSCLC(83.9%). Most pattern of p16 gene deletion was loss of heterozygosity(LOH). The deletion of p16 gene was not significanfly associated with histological type or cell differentiation, as well as metastasis and clinical stage of NSCLC. In stage I and Ⅱ NSCLC, the obvious deletion of p16 gene was examined. Conclusion: p16 gene may play importmant role in genesis and progression of NSCLC.Deletion of p16 gene may be an early event of lung cancer, and may be of importance for early diagnosis of lung cancers.
【Fund】: 江苏省科技厅立项课题 (BS2 0 0 2 3 64 )
【CateGory Index】: R734.2
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【Co-citations】
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1 ZHANG Pei-qi(College of Life Sciences,Nanjing Agricultural University,Nanjing 210095,PRC);The Determinants of Epigenetics of Cancer[J];湖南农业科学;2010-19
2 LI Dian-ming, XIA Xue-mei, LIU Chao, CHEN Yu-qing, CAI Ying-yun. Department of Respiratory Diseases, Affiliated Hospital, Bengbu Medical College, Bengbu 233004, China;The significance of FHIT gene detection for the diagnosis of lung cancer in transbronchial biopsy tissue samples and sputum samples[J];实用医学杂志;2008-21
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6 ZHANG LI-JIAN (Department of Oncology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China);A PRELIMINARY STUDY OF RADIOTHERAPEUTIC TARGET REGION DESIGN FOR NSCLC BY DETECTION OF p16 GENE METHYLATION[J];齐鲁医学杂志;2007-04
7 Wenhu Tao1,Yongtang Jin2,Zaicheng Yu1,Xiao Liu1 1 Department of Thoracic Surgery,the First Affiliated Hospital,Anhui Medical University,Hefei 230022,China 2 School of Public Health,Anhui Medical University,Hefei 230022,China;The effects of CYP1A1 gene polymorphism and p16 gene methylation on the risk of lung cancer in a Chinese population[J];Chinese-German Journal of Clinical Oncology;2007-04
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【Co-references】
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1 CHEN Ping1, LI Jian2, YIN Kai-sheng1, YU Li-chao3 (1. Department of Respiration, the First Affilicated Hospital of Nanjing Medical University, Nanjing 210029; 2.Department of Respiration 3.Department of Chest, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001,China);Studies On the Deletion of p16 Gene in Non-small Cell Lung Cancer[J];江苏大学学报(医学版);2004-02
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1 ZHENG Jun-sheng1,ZHOU Jie1,LI Xiao-mao1,LIN Chen-li2 (1Department of Obstetrics & Gynecology,Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;2Department of Pathology,School of Medicine,Jinan University,Guangzhou 510632,China);Effect of sodium selenite on proliferation of endometrial cancer cells[J];中国病理生理杂志;2011-12
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