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《Journal of Jiangsu University(Medicine Edition)》 2008-05
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Effect of pyrroloquinoline quinone on free radical in rats with radiation-induced skin injury

WU Qi-sheng,WANG Jian-hao,ZHOU Ying-hui,QIN Fang,SHEN Li,WU Shi-liang(Department of Biochemistry and Molecular Chemistry,Institute of Biochemistry Engineering,Soochow University,Suzhou Jiangsu 215123,China)  
Objective: To investigate PQQ scavenging free radicals in skin and serum of SD rats after linear accelerator radiation acute skin injury.Methods: The animal model of linear accelerator radiation injury was established,by PQQ oral administrations and jetting administrations,the contents of MDA,NOS,SOD in skin and serum were measured. Results: After PQQ administrations,to PQQ not-treating group,the contents of MDA and NOS decreased,were higher than the normal group(P0.05);while the contents of SOD in skin increased,were lower than the normal group(P0.05),the changes of SOD in serum had no significance. Conclusion: PQQ can effectively improve the activities of the free radical scavenging enzymes,partly decrease free radicals produced by linear accelerator radiation,but can not reach the normal level.
【Fund】: 国防重点子项目基金资助(A3820060130)
【CateGory Index】: R818.71
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【References】
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1 QIU Xiu-qin1,2,LIU Chun-liang1,XU Lan1,ZHAO Jun-yu1,WU Shi-liang1(1.Department of Biochemistry and Molecular Biology,Institute of Biochemistry Engineering,Soochow University,Suzhou Jiangsu 215123;2.Suzhou Health College,Suzhou Jiangsu 215009,China);Effect of pyrroloquinoline quinine on anti-oxidative competence of AGS cell radiated by γ-ray[J];Journal of Jiangsu University(Medicine Edition);2009-04
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