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《Journal of Jiangsu University(Medicine Edition)》 2009-04
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Effect of pyrroloquinoline quinine on anti-oxidative competence of AGS cell radiated by γ-ray

QIU Xiu-qin1,2,LIU Chun-liang1,XU Lan1,ZHAO Jun-yu1,WU Shi-liang1(1.Department of Biochemistry and Molecular Biology,Institute of Biochemistry Engineering,Soochow University,Suzhou Jiangsu 215123;2.Suzhou Health College,Suzhou Jiangsu 215009,China)  
Objective:To investigate PQQ scavenging free radicals in cells by γ-ray radiation.Methods:AGS cells were cultivated.There were 6 groups in our experiment:the normal group,simply irradiated group,nonirradiated group treated with PQQ by 12 hours,nonirradiated groups treated with PQQ by 4 hours,irradiated groups treated with PQQ by 12 hours,irradiated groups treated with PQQ by 4 hours.The radiation was 60Coγ-rays with the dose of 8Gy.After irradiated 6 h,12 h,24 h,the cells were measured of theses level:total antioxidation competence(T-AOC),SOD,MDA. Results:The level of T-AOC and SOD decreased(P0.05),and the level of MDA increased(P0.01)in simply irradiated groups after irradiated 6 h,12 h,24 h,in comparison with the normal group.The level of T-AOC and SOD increased(P0.01) in irradiated groups treated with PQQ in comparison with the simply irradiated group;and the level of MDA decreased(P0.05). Conclusion:PQQ can protect radiated cells,by strengthening anti-oxidative competence and lessening the oxidation of cells.
【Fund】: 国防基础科研重点基金资助子项目(A3820060130)
【CateGory Index】: R965
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1 WU Qi-sheng,WANG Jian-hao,ZHOU Ying-hui,QIN Fang,SHEN Li,WU Shi-liang(Department of Biochemistry and Molecular Chemistry,Institute of Biochemistry Engineering,Soochow University,Suzhou Jiangsu 215123,China);Effect of pyrroloquinoline quinone on free radical in rats with radiation-induced skin injury[J];Journal of Jiangsu University(Medicine Edition);2008-05
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1 Li Haohuan,Liu Shiqing,Peng Hao Department of Orthopedics,Remin Hospital,Wuhan University,Wuhan 430060,China;Effect of Pyrroloquinoline Quinone on Recovery of Injured Peripheral Nerve[J];Journal of Hubei Medical University;2004-02
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9 WANG Xin~ 1,2,3 ,WANG Jian-hua~1,LIU Dang-sheng~2,ZHANG Wei-cai~ 1 ( ~1 Beijing Institute of Biotechnology,Beijing 100071,China)( ~2 Institute of Life Sciences and Biological pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)( ~3 Institute of Life Sciences,Heilongjiang University,Haerbin 150080,China);Establishment of the screening method and isolation of PQQ producing strains[J];Acta Microbiologica Sinica;2007-06
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【Secondary Citations】
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1 Qiu Hao,Zhou Yinghui,Xu Lan,Shi Ning,Wu Shiliang (Department of Biochemistry and Molecular Biology,Suzhou University,Suzhou,215007);The Changes of Free Radicals in SD mice after Linear Accelerator Radiation Injury[J];Chinese Journal of Hemorheology;2001-02
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