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《Journal of Jiangsu University(Medicine Edition)》 2009-04
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Effect of pyrroloquinoline quinine on anti-oxidative competence of AGS cell radiated by γ-ray

QIU Xiu-qin1,2,LIU Chun-liang1,XU Lan1,ZHAO Jun-yu1,WU Shi-liang1(1.Department of Biochemistry and Molecular Biology,Institute of Biochemistry Engineering,Soochow University,Suzhou Jiangsu 215123;2.Suzhou Health College,Suzhou Jiangsu 215009,China)  
Objective:To investigate PQQ scavenging free radicals in cells by γ-ray radiation.Methods:AGS cells were cultivated.There were 6 groups in our experiment:the normal group,simply irradiated group,nonirradiated group treated with PQQ by 12 hours,nonirradiated groups treated with PQQ by 4 hours,irradiated groups treated with PQQ by 12 hours,irradiated groups treated with PQQ by 4 hours.The radiation was 60Coγ-rays with the dose of 8Gy.After irradiated 6 h,12 h,24 h,the cells were measured of theses level:total antioxidation competence(T-AOC),SOD,MDA. Results:The level of T-AOC and SOD decreased(P0.05),and the level of MDA increased(P0.01)in simply irradiated groups after irradiated 6 h,12 h,24 h,in comparison with the normal group.The level of T-AOC and SOD increased(P0.01) in irradiated groups treated with PQQ in comparison with the simply irradiated group;and the level of MDA decreased(P0.05). Conclusion:PQQ can protect radiated cells,by strengthening anti-oxidative competence and lessening the oxidation of cells.
【Fund】: 国防基础科研重点基金资助子项目(A3820060130)
【CateGory Index】: R965
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WU Qi-sheng,WANG Jian-hao,ZHOU Ying-hui,QIN Fang,SHEN Li,WU Shi-liang(Department of Biochemistry and Molecular Chemistry,Institute of Biochemistry Engineering,Soochow University,Suzhou Jiangsu 215123,China);Effect of pyrroloquinoline quinone on free radical in rats with radiation-induced skin injury[J];Journal of Jiangsu University(Medicine Edition);2008-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Li Haohuan,Liu Shiqing,Peng Hao Department of Orthopedics,Remin Hospital,Wuhan University,Wuhan 430060,China;Effect of Pyrroloquinoline Quinone on Recovery of Injured Peripheral Nerve[J];Journal of Hubei Medical University;2004-02
2 ZHU Xin-jie1,CHENG Yao2(1.NCPC New Drug Research and Development Co.,Ltd,Shijiazhuang 050015,China;2.Hebei Jiupai Phamnaceutical Co.,Ltd,Shijiazhuang 052165,China);Research Progress of Pyrroloquinoline-quinone[J];Hebei Chemical Industry;2011-05
3 XIONG Shun-hua,GUO Qing-ping,TANG Jun-ming,LIU Yan-li(Department of physiology,Yunyang Medical college,Shiyan 442000,China);Effect of PQQ on the hippocampal neurons of aging rat induced by D-galactose[J];Basic & Clinical Medicine;2006-09
4 Zhang Chunli1,Zou Yang2,Lin Jingde1,Wen Chuanjun2,Shen Gan3*(1Friendship Plastic Surgery Hospital,NJMU,Nanjing 210029;2Colleg of Sciences,Nangjing Normal University,Nanjing 210023;3Department of Plastic Surgery,the Second Affiliated Hospital to NJMU,Nanjing 210003,China);Protective effect and mechanism of pyrroloquinoline quinine (PQQ) against UVA induced human skin fibroblasts aging[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2013-03
5 HE Bin,LIU Shi-qing,LI Hao-huan (Renmin Hospital of Wuhan University,Wuhan,430060,P.R.China);Effects of pyrroloquinoline quinone on proliferation and expression of EGR1 and EGR2 gene on cultured Schwann cells of rats[J];Shandong Medical Journal;2010-14
6 QIU Xiu-qin1,2,WANG Ze-rong1,3,XU Lan1,LIU Chun-liang1,WU Shi-liang1 (1.School of Preclinical Medicine and Biological Sciences,Soochow University,Suzhou 215123,China;2.Suzhou Health College,Suzhou 215009,China;3.The No.5 People's Hospital of Suzhou,Suzhou 215007,China);The preliminary study on the role of pyrroloquinoline quinine on a rat model of liver fibrosis[J];Chinese Journal of Biochemical Pharmaceutics;2010-05
7 Xiong Shunhua,Wang Yan,Tang Wei(Department of physiology,Yunyang Medical College,Shiyan 442000);CHANGE OF MORPHOSIS OF THE HIPPOCAMPAL FORMATION INDUCED BY PQQ LATERAL VENTRICLE INJECTION IN THE RAT[J];Chinese Journal of Neuroanatomy;2007-05
8 Department of Physiology,Yunyang Medical College(Shiyan 442000)Xiong Shunhua Wang Jun Gong Jian et al;Effects of pyrroloquinoline quinone on the growth of hippocampal neurons cultured in vitro[J];Shaanxi Medical Journal;2007-05
9 WANG Xin~ 1,2,3 ,WANG Jian-hua~1,LIU Dang-sheng~2,ZHANG Wei-cai~ 1 ( ~1 Beijing Institute of Biotechnology,Beijing 100071,China)( ~2 Institute of Life Sciences and Biological pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)( ~3 Institute of Life Sciences,Heilongjiang University,Haerbin 150080,China);Establishment of the screening method and isolation of PQQ producing strains[J];Acta Microbiologica Sinica;2007-06
10 LI Min1,2,DU Guo-cheng*1,2,CHEN Jian1,2(1.Key Laboratory of Industrial Biotechnology,Ministry of Education,Jiangnan University,Wuxi 214122,China;2.School of Biotechnology,Jiangnan University,Wuxi 214122,China);Biodegradation of Polyvinyl Alcohol[J];Journal of Food Science and Biotechnology;2008-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Qiu Hao,Zhou Yinghui,Xu Lan,Shi Ning,Wu Shiliang (Department of Biochemistry and Molecular Biology,Suzhou University,Suzhou,215007);The Changes of Free Radicals in SD mice after Linear Accelerator Radiation Injury[J];Chinese Journal of Hemorheology;2001-02
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