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《Zhejiang Journal of Integrated Traditional Chinese and Western Medicine》 2009-03
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Intercellular Adhesion Molecule-1 in Lung Injury of Cardiaopulmonary Bypass and the Protective Effect of Shenmai Injection

WANG Jun,et al.The First Affiliated Hospital of Wenzhou Medical College,Wenzhou,325000,China  
Objective:To observe the influence of Shenmai injection on intercellular adhesion molecule-1(ICAM-1) in lung injury by cardiopulmonary bypass(CPB) and to explore the underlying mechanism of the protective effect of Shenmai injection on organ damage.Methods:Thirty patients undergoing open heart surgery under CPB for cardiac valve replacement were randomized into a treatment group intravenously infused by physiological saline 250 ml with 0.6 ml/kg Shenmai injection and a control group by physiological saline 250 ml alone,15 patients each.Other anesthesia procedures remained the same in the 2 groups.Blood samples were taken from radial artery before the induction of anesthesia and at 0.5,2,6,24 hours after terminating CPB for blood gas analysis and serum ICAM-1 determination.Results:In both groups,alveolar-arterial oxygen difference,respiratory index,and the level of ICAM-1 showed no difference before anesthesia but all increased after terminating CPB(P0.05 or P0.01).Compared to the control group,these indexes were reduced in the treatment group(P0.05 or P0.01).Conclusion:Shenmai injection has protective effects on lung injury induced by CPB through inhibiting ICAM-1.
【Fund】: 浙江省中医药管理局科研基金(No.2008CA071)
【CateGory Index】: R285.5;R654.1
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