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《Chinese Journal of Spine and Spinal Cord》 2009-10
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The express of tumor nerosis factor-α and protein gene product 9.5 in the lumbar disc displayed the high intensity zone on MRI

REN Dongfeng,HOU Shuxun,WU Wenwen,et al Department of Orthopaedics,the First Affiliated Hospital of General Hospital of Chinese People′s Liberation Army,Beijing,100037,China  
Objective:To observe the association of tumor nerosis factor-α(TNF-α) and protein gene product 9.5(PGP9.5) with the high intensity zone(HIZ) of the lumbar disc on MRI.Method:26 cases with discogenic back pain diagnosed by discography showed high intensity zone(HIZ) on T2 MRI in lumbar intervertebral disc,there were 16 males and 10 females,aged from 26-65 years.All cases underwent surgical treatment and discs were harvested during surgery.Disc samples were immunostained using antibodies to TNF-α and PGP9.5,which were compared with controls requiring surgery for scoliosis(n=4).Result:The histologic study of the consecutive sagittal slices of the HIZ showed vascularized granulation tissue and degenerated nucleus pul-posus,a lot of proliferated small round cells and fibroblasts presented,blood proliferation and inflammatory cells infiltration were also seen.TNF-α and PGP9.5 immunostain positive cells were found in the experimental group and not found in the control group.The number of TNF-α and PGP9.5 immunostain positive cells were significantly higher in HIZ than that in the annulus fibrosus around HIZ and that of the control group(P 0.05).Conclusion:High TNF-α and PGP9.5 expression in HIZ on MRI in the anulus fibrosus of patients with low back pain may indicate the inflammation mechanism for HIZ as specificity sign of painful disc on MRI.
【CateGory Index】: R681.5;R445.2
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