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《Journal of University of Science and Technology of China》 2009-01
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Action of glycine,lysine,tyrosine and methionine in Micromonospora echinospora

GUAN Yu-xia1,ZHANG Hong-xiu2,LUO Hong1,TANG Cui1(1.College of Biological Science and Technology,Fuzhou University,Fuzhou 350002,China;2.Shandong Academy of Enviromental Science,Jinan 250013,China)  
The promoters(amino acids) were screened out by the orthogonal design in the course of biosynthesis micronomicin from the mutant strain(Fzu-707) of Micromonospora echinospora.Certain amount of glycine,lysine,tyrosine and methionine was added to the original medium in a flask on the rotary shaker 220 r/min and incubated at 36 ℃.It was propitious to biosynthesize micronomicin in cells of Micromonospora echinospora.The fermentation time was shortened from 144 h to 104 h,the yield of micronomicin(u·mL-1) was increased about 20% compared with the control group and the production rate of micronomicin was increased about 60%.
【CateGory Index】: TQ465
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