Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Rehabilitation Theory & Practice》 2004-08
Add to Favorite Get Latest Update

Secondary injury to perihematoma in intracerebral haemorrhage rats

ZHAO Xing quan, ZHOU Jian, WANG Yong jun. Department of Neurology, Beijing Tiantan Hospital, Beijing 100050, China  
ObjectiveTo study possible mechanism through investigating the pathological and ultrastructural characters of secondary injury to perihematoma in intracerebral haemorrhage (ICH) rats.MethodsSprague Dawley male rats were subjected to ICH models. They were randomly divided into test group and control group. The rats in the test group were divided into 7 subgroups at 1 h, 3 h, 12 h, 24 h, 48 h, 72 h and 7 d after ICH; while those in control group were divided into 3 subgroups at 3 h, 24 h, 72 h after saline injection. Each subgroup contained 5 rats. 2 rats from each group were stained by 2% triphenyltetrazolium chloride(TTC) to observe the pathological change.3 rats were picked up from each group to do optical microscope and electric microscope investigation on perihematoma tissue and ipsilateral cortex.ResultsHematoma tissue was demonstrated as black brown by TTC staining, no white infarcted area was detected around hematoma. In addition, there was a transitional zone between hematoma and normal tissue under microscopy; the involved tissue looked loose with varied edematous cells. Astrocytes appeared swollen and neural cells looked degenerated and necrosis. Meanwhile, capillary hyperplasia around hematoma with foot plate swollen were detected, no remarkable neural cells change was observed. 24 h after blood injection, astrocytes started to swell, part of them became degenerated and necrosis. Neural cells appeared mild degenerated and blood brain barrier were destroyed. 72 h after ICH, astrocytes showed highly swollen with neural cells degenerated.ConclusionSecondary injury to perihematoma has been identified and the pathological and ultrastructural changes have been observed.
【CateGory Index】: R743.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 5 Hits
1 LI Xiao-wei(Department of Neurosurgery, Harrison International Peace Hospital, Hengshui 053000);Analysis of surgical treatment of 126 cases of basal ganglia intracerebral haemorrhage[J];Beijing Medical Journal;2007-03
2 LI Guan-dong, HUANG Bin-hao, LI Bing-hua, HUANG Huan-zhang, ZHONG Jian-xin, TANG Kai-xiong, CHEN Xue-zhong, LAI Sui-pian (Department of Neurology Medicine, Jiangmen City Central Hospital, Guangdong Province, Jiangmen 529070, China);Detection of Brain Hypoxic Tissue in the Patients with Hypertensive Cerebral Hemorrhage Using ~(99)Tc~m HL91 SPECT/CT Imaging[J];Journal of Tropical Medicine;2006-02
3 WANG Tao, ZHAO Ji-zong, SUN Yi-lin, et al.The Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China;Changes of the ultrastructure of global cerebral ischemia and reperfusion damage in rats[J];Chinese Journal of Rehabilitation Theory and Practice;2006-01
4 LI Hong-ling, LIU Rui-chun, GOU Yuan-chong, et al. The Department of Rehabilitation, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China;An Intracerebral Hemorrhage Model Established by Autologous Blood Injection Three Times in Rat[J];Chinese Journal of Rehabilitation Theory and Practice;2006-08
5 ZHANG Jian-hong,ZHANG Yan,CHEN Qiong.Department of Neurology,Xinyang Central Hospital,Xinyang 464000,China;Rehabilitation Nursing of the Patients with Sever Ventricular Hemorrhage[J];Chinese Journal of Rehabilitation;2006-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LIU Qiang,CHEN Zhi-gang,MENG Fan-xing,GUO Rong-juan,HAN Gang,LIN Can,WANG Le,MA Li-zhen(Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China);Preliminary investigation of correlation between distributions of TCM syndromes and background diseases in acute stage of apoplexy[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-07
2 TANG Xun1,4,ZHU Yan-ping1,4,LI Na1,4,CHEN Da-fang1,4,ZHANG Zong-xin2,DOU Hui-dong3,HU Yong-hua1,4△(1.Department of Epidemiology & Biostatistics,Peking University School of Public Health,Beijing 100083,China;2.Department of Neurology,3.Department of Clinical Laboratory Medicine,The First Hospital of Fangshan District;4.Key Laboratory of Epidemiology,Ministry of Education);Genetic epidemiological study on discordant sib pairs of ischemic stroke in Beijing Fangshan District[J];Journal of Peking University(Health Sciences);2007-02
3 ZHANG Yanping, Lu Changchun, ZHANG Jifen, ZHANG Pan, WU Tiejun, WANG Jingquan Department of Neurosurgery, Central Hospital of Zibo Mining Corporation (Group), Zibo 255120, China;Application of minimally invasive CT-guided surgery in the treatment of hypertensive intracerebral hemorrhage disrupting into intraventricular system[J];Chinese Journal of Neuromedicine;2003-06
4 SHI Xiangqun~1, YANG Jinsheng~1, ZHANG Zhilin~2, WANG Yunliang~2, BAO Shiyao~2 1 Department of Neurology, Lanzhou General Hospital of PLA, Lanzhou 730050, China; 2 Department of Neurology, Second Affiliated Hospital of Suzhou University, Suzhou 215004, China;Distribution of Aquaporin 4 in normal rat brain[J];Chinese Journal of Neuromedicine;2004-04
5 CHU Zhao-hu*,FEI Shi-zao,MA Ling-song*,ZHOU Xiang-yang,WU Jia-mi*. *Department of Neurology,Yijishan Hospital,Wannan Medical College,Wuhu 241001,China;Expression of IGF-1 in rat brain and its effect on apoptosis after intracerebral hemorrhage[J];Chinese Journal of Neuromedicine;2006-11
6 WANG Lei1,LI Chang-qing2,HU Chang-lin2(1.Department of Neurology,Third People's Hosptal of Chengdu City,Chengdu,Sichuang 610031,China;2.Department of Neurology,Second Affiliated Hospital,Chongqing University of Meidcal Sciences,Chongqing 400010,China);Study of cardiac damage following experimental stroke[J];Chongqing Medicine;2008-06
7 Wang Kewan; Yang Zhihuan; Wang Zhengguo ;et al.(The Traffic Medicine Institute,Daping Hospital,Third Military Medical University,Chongqing 400042);The Early Reactive Feature of Astrocytes after Traumatic Brain Injury in Rats[J];JOURNAL OF TRAUMATIC SURGERY;1999-03
8 BAI Ying, et al (Affiliated Hospital of Medical College of Dalian University, Dalian 116621, China);Study on the Changes of Serum NSE Levels and Cerebral Morphology in a Rat Cerebral Ischemia-Reperfusion Model[J];Journal of Dalian University;2001-02
9 ZHANG Yan ling, CHEN Kang ning, SHAO Shu qin, WANG Ying (Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing 400038,China);Establishment of rat cerebral hemorrhage model by type Ⅳcollagenase injection[J];Acta Academiae Medicinae Militaris Tertiae;2002-12
10 Li Qian Wenzhou Medical College, Wenzhou (325003) Chen Xinghua Department of Neurology, Xin Hua Hospital, Shanghai Second Medical University, Shanghai (200092);Clinical Significance of Changes of Serum Lipoprotein(a) Levels in Patients with Cerebral Vascular Accidents[J];Journal of Radioimmunology;2004-06
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 Chen Yasong,Wu Lixin,He Xuelai Department of Internal Medicine,the People's Hospital of Susong County,Anqing 246501;The effect analysis of microinvasive evacuation of hematoma in treatment 24 patients with intracerebral hemorrhage[J];Anhui Medical Journal;2009-07
2 ZHANG Dong, WANG Shuo, ZHAO Yuan-li, et al (Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050);Surgical treatment of hypertensive putaminal hematomas through transsylvian-insular approach[J];Beijing Medical Journal;2008-02
3 LI Xin,JI Nan,ZHAO Yuan-li,ZHAO Ji-zong(Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,P.R.China);Clinical forecast research of secondary brain edema on the patients with spontaneous intracerebral hemorrhage[J];Shandong Medical Journal;2008-28
4 YANG Fan,BIN Jian-ping,NONG Sheng-xiong,CHEN Shao-min,LI Chong-xin,WANG Peng Department of Cardiology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;The characteristics and significance of Doppler tissue imaging in hypertensive patients with or without left ventricular hypertrophy[J];The Journal of Practical Medicine;2008-05
5 CHEN Jun,LU Ya-qin,Lü Hai-hong,et al.The Department of Neurology,Lanzhou University First Hospital,Lanzhou 730000,Gansu,China;Protective Effects of Naoxintong Capsule on Cerebral Ischemia-reperfusion Injury in Rats[J];Chinese Journal of Rehabilitation Theory and Practice;2009-02
6 LIU Jian,FAN Hai-xia,YANG Mei-yun,et al.The First Affiliated Hospital of Anhui College of TCM,Hefei 230031,China;The Changes in Behaviors and Brain Amino Acids and Neurocyte Ultrastructure in Rats with Adjuvant Arthritis and Effects of Xinfeng Capsule[J];Chinese Journal of Rehabilitation;2008-04
7 GAO Chen, LIU Yao-ming, CHENG Gang, et al. Department of Trauma Surgery, General Hospital of Lanzhou Military Command, Lanzhou 730070, China;Comparative Study on Edaravone vs Dexamethasone in the Treatment of Patients with Traumatic Brain Injury[J];Chinese Journal of Rehabilitation;2008-06
8 SHI Baozhong, HAO Xiaowei, LUO Donghui, LIU Jinfang, XU Lixin, LIU Yunsheng. Department of Neurosurgery, The First Affiliated Hospital of Henan Science & Technology University, No.24, Jinghua Road, Luoyang. 471003.;Effect of erythrocyte on brain water content and expression of HO-1 in rat with traumatic intracerebral hemorrhage[J];Chinese Journal of Nervous and Mental Diseases;2007-11
9 Lin Can,Zhang Yunling,Chen Zhigang,et al Department of Neurology,Dongfang Hospital,Beijing University of Traditional Chinese Medicine(Beijing 100078);The Effect of Panax Notoginseng Saponins on Intracerebral Hemodynamics in Acute Basal Ganglia Hemorrhage[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2007-11
China Proceedings of conference Full-text Database 1 Hits
1 Liu Jian Fan Haixia Yang Meiyun Yu Yuefang (The First Affiliated Hospital of Anhui College of TCM,Hefei 230031);The Changes and Effects of Xinfeng Capsule on Behaviors and Brain Amino Acids and Neurocyte Ultrastructure in Adjuvant Arthritis Rats[A];[C];2008
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved