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《Chinese Journal of Antibiotics》 1984-02
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STUDIES ON SAGAMICIN PRODUCED BY M. ECHINOSPORA MUTANT STRAIN Ⅲ. ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF ANTIBIOTCS 401-B

Fan Jin and Zhao Min (Jiangsu Institute of Microbiology, Wuxi)  
A mutant strain of M.echinospora JIM-401, produced an antibiotic complex consisting primarily of 401-A, 401-B. They were isolated from fermentation broth by using of a cationic exchange resin and silica-gel column chromatography. Antibiotic 401-A was identified as Gen-tamicin C_(la), and Antibiotic 401-B was to be identical to sagamicin (Gentamicin C_(2b),) in the IR, NMR, MS spectra as well as chemical and biological properties. The in vitro antibacterial of antibiotic 401-B showed similarity to gentamicin C complex. Antibiotic 401-B has an intravenous acute LD_(50) in mice of 126±7.5mg/kg.
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【References】
Chinese Journal Full-text Database 1 Hits
1 Zhao Min;Xie Fenglong;Wang Jie;Yang Xiaowei and Fan Jin (Jiangsu Institute of Microbiology,Wuxi 214063);Studies on formation ,regeneration and fusion of protoplast in Micromonospora echinospora var.producer of micronomicin[J];CHINESE JOURNAL OF NATIBIOTICS;1995-01
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 Zhao Min, Fan Jin, Bo Jian-xin Bu Hua-xiang(Jiangsu Province Research Institute of Microbiology, Wuxi);STUDIES ON THE SAGAMICIN PRODUCED BY MICROMONOSPORA ECHINOSPORA MUTANT STRAIN——I. TAXONOMICAL IDENTIFICATION OF M.ECHINOSPORA JIM-401[J];;1983-05
2 Zhao Min, Fan Jin and Bo Jian-xin (Jiangsu Institute of Microbiology, Wuxi);STUDIES ON SAGAMICIN PRODUCED BY M.ECHINOSPORA MUTANT STRAIN II. SELECTION AND FERMENTATION OF M.ECHINOSPORA JIM-401[J];;1984-02
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Chinese Journal Full-text Database 5 Hits
1 Qiang Hua 1, Chen Wenlie 2, Zhong Xiurong 2, et al (1.Departement of Microbiology,\ 2.Laboratory of Electron Microscopy, Fujian Medical University, Fuzhou, 350004);Observations on the Formation and Release of the Protoplasts from Streptomyces hygroscopicus FC904[J];JOURNAL OF FUJIAN MEDICAL UNIVERSITY;1999-01
2 LU Ming,QI Ru-feng,XU Pei-jun,et al (Department of Microbiology,Suzhou Unirersity,Suzhou 215007,China);The Utilization of Ultrasonication in Mutagenic Breeding of Protoplast[J];Acta Academiae Medicinae Suzhou;2001-04
3 GUAN Yu-xia LAN Ji-xian YAN Guang-xing ZHENG Jing-shi(College of Biological Science and Technology,Fuzhou University,Fuzhou 350002,China);Study on the High Yield Strain of Gentamicin Producer by Protoplast Fused and Fermentor Test[J];China Biotechnology;2009-08
4 GUAN Yu-xia1,ZHANG Hong-xiu2,LUO Hong1,TANG Cui1(1.College of Biological Science and Technology,Fuzhou University,Fuzhou 350002,China;2.Shandong Academy of Enviromental Science,Jinan 250013,China);Action of glycine,lysine,tyrosine and methionine in Micromonospora echinospora[J];Journal of University of Science and Technology of China;2009-01
5 Cui Dapeng and Shi Lianying (Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050);Improvement of thienamycin producing strain by regeneration and mutagenesis of protoplasts[J];CHINESE JOURNAL OF ANTIBIOTICS;1999-04
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