Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF ANTIBIOTICS》 1999-06
Add to Favorite Get Latest Update

Screening, purification and pharmacological study on a IL-1R antagonist Streptomyces 139

Wu Qian, Wu Jianbo and Li Yuan (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050)  
Based on competitive receptor ligand binding assay, a new bioassay for screening IL 1R antagonists has been developed. It has been used in screening of a novel IL 1R antagonists from actinomyccetes. Streptomyces 139 is an active strain, one of whose metabolites is a strong sIL 1R antagonist, which is characterized as a polysaccharide.
【Fund】: 国家自然科学基金!资助项目(39670016)
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 5 Hits
1 He Xiao-bo and Si Shu-yi(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100050);Advances in the research of active polysaccharides derived from microbes[J];中国抗生素杂志;2006-02
2 WANG Ling-Yan,LI Shi-Tao,GUO Lian-Hong,JIANG Rong,LI Yuan ① (Institute of Medicinal Biotechnology,Chinese Academy of Medical,Beijing 100050,China);Cloning and Identification of the Priming Glycosyltransferase Gene Involved in Exopolysaccharide 139A Biosynthesis in Streptomyces[J];遗传学报;2003-08
3 Du Kang ping, Jiang Rong, Li Bao yi, Wu Jian bo and Li Yuan (Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100050);IL-1R antagonists from microorganisms II. Studies on the metabolite of streptomyces 660[J];中国抗生素杂志;2001-06
4 Li Quan- wen, Bian Xin, Zhang Yang and Li Yuan (Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing10 0 0 5 0 );Study of the screening model for IL-1 receptor antagonists[J];中国抗生素杂志;2000-05
5 Li Yuan (Department of Bioengineering, Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050,China);Introduction of the High Throughput Screening System[J];中国医学科学院学报;2000-02
【Co-references】
Chinese Journal Full-text Database 6 Hits
1 WANG Ling-Yan,LI Shi-Tao,GUO Lian-Hong,JIANG Rong,LI Yuan ① (Institute of Medicinal Biotechnology,Chinese Academy of Medical,Beijing 100050,China);Cloning and Identification of the Priming Glycosyltransferase Gene Involved in Exopolysaccharide 139A Biosynthesis in Streptomyces[J];遗传学报;2003-08
2 CHEN Jing 1, WU Jian bo 1, LIU Ye min 2, XU Gui yun 2 (1. Institute of Medical Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; 2. Institute of Chemistry, Chinese Academy of Sciences,;STUDY ON THE STRUCTURAL PROPERTY OF POLYSACCHRIDES 139A A KIND OF IL-1R ANTAGONISTS FROM MICROORGANISM[J];药学学报;2001-10
3 Wang Changyun\ Guan Huashi (Marine Drug and Food Institute,Ocean University of Qingdao,Qingdao 2669003);Advances of Researches on Antiviral Activities of Polysaccharides Ⅰ Antiviral Activities of Polysaccharides[J];生物工程进展;2000-01
4 Wu Qian, Wu Jianbo and Li Yuan (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050);Screening, purification and pharmacological study on a IL-1R antagonist Streptomyces 139[J];中国抗生素杂志;1999-06
5 Meng Xiaofeng, Peng Jian, Gong Bingyong and Zhu Baoquan(Shanghai Institute of Pharmaceutical Industry, SPAC, Shanghai 200040);Study on compound SIPI-94-1129-Ⅰ,a inhibitor of factor ⅩⅢa from microorganism[J];中国抗生素杂志;1998-04
6 HU Hai-Feng; ZHU Bao-Quan; GONG Binog-Yong (Shanghai Institute of Pharmaceutical Industry, Shanghai 200040);INHIBITOR OF CHOLESTEROL BIOSYNTHETIC ENZYME FROM MICROORGANISMS:STUDIES ON ANTIBIOTIC SIPI-8926-111[J];中国医药工业杂志;1995-11
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 KANG Min;WANG Ze-yu;GUO Da-le;HU Jia;ZHOU Yan;DING Li-sheng;DENG Yun;Key Laboratory of Standardization of Chinese Herbal Medicine,Ministry of Education,State Key Laboratory Breeding of Systematic Research Development and Utilization of Chinese Medical Resources,Co-founded by Sichuan Province and MOST,Pharmacy Department,Chengdu University of Traditional Chinese Medicine;Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization,Chengdu Institute of Biology,Chinese Academy of Sciences;;Chemical Constituents of n-Butanol Extract of Myrothecium verrucaria[J];中药材;2016-03
2 NIE Kun-lun1,2,HE Li3,SU Xiao-juan1,2,BIAN Jin-lin1,2,GUO Jin-long1,DU Xiao1,2,*(1.R&D Center,National Tea Inspection Center(Sichuan),Sichuan Agricultural University,Ya’an 625014,China;2.National Tea Quality Inspection Center(Sichuan),Ya’an 625014,China;3.College of Food Science,Sichuan Agricultural University,Ya’an 625014,China);Screening and Evaluation of α-Amylase-inhibiting Fractions Extracted from Ya’an Tibetan Tea[J];食品科学;2013-09
3 CAI Juan-ni,WEI Qi-qiu,ZHANG De-zhi,WEN Lu,MIN Ying,CHEN Gang(School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China);A Preliminary Study of Exopolysaccharides from A Marine Actinomycete[J];化学与生物工程;2011-09
4 JIANG Xiao-Lu,GUO Jing,LI Rong(College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China);Study of Exopolysaccharide Production from Rahnella sp. PJT09 by Fermentation[J];中国海洋大学学报(自然科学版);2010-08
5 WANG Gui-lan1,2,LING Pei-xue1,2(1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;2.Post-doctoral Scientific Research Workstation,Institute of Biopharmaceuticals of Shandong Province,Jinan 250101,China);Progress on Extraction and Isolation Technologies of Bacterial Exocellular Polysaccharides[J];食品与药品;2010-05
6 Yang Ning,LiuAnjun (College of Food Engineering and Biotechnology,Tianjin University of Science and Technology, Tianjin 300457,China);Study on the growth inhibitory effects of cartilage polysaccharide on L1210 cells[J];中国科技论文在线;2009-09
7 Zhu Changliang1 Yang Hongying2 Jia Bingguo1 Xu Chunju1Li Jinliang3 Fan Youjing2 Pi Guangzhi1 Li Wenzhi3(1.Hebei Hanxing Institute of Mine & Metallurgy Design Co.Ltd;2.Northeastern University;3.Inner Mongolia Weilastuo Mining Co.Ltd);Status Quo of Engineering Application of Extracellular Polymeric Substances (EPS) from Bacteria and Progress in Its Research[J];金属矿山;2008-02
8 ZHAO Wen-Ying1,2,GU Qian-Qun1,ZHU Wei-Ming1(1.Key Laboratory of Marine Drugs of MEC,School of Medicine and Pharmacy,Oean University of China,Qingdao 266003,China;2.Qingdao University of Science and Technology,Qingdao 266042,China);Studies on the Antitumor Constituents of Marine Sponge Derived Actinomycete SH6004[J];中国海洋大学学报(自然科学版);2008-01
9 ZHAO Wen-ying1,2,Zhu Qing-shu1,GU Qian-qun2(1.College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China;2.Key Laboratory of Marine Drugs,Ministry of Education,Ocean University of China,Qingdao 266003,China);Studies on the Chemical Constituents of Secondary Metabolites of Marine-derived Aspergillus fumigatus(Ⅱ)[J];青岛科技大学学报(自然科学版);2007-05
10 LIU An-jun YANG Ning ZHANG Guo-rong (College of Food Engineering and Biotechnology,Tianjin University of Science and Technology,Tianjin 300457 China);Study on Growth Inhibitory Effect of Cartilage Polysaccharide on L1210 Leukaemia Mice[J];现代生物医学进展;2007-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved