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《CHINESE JOURNAL OF NATIBIOTICS》 1997-06
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Effects of fleroxacin hydrochloride on bacterial biofilm induced by Pseudomonas aeruginosa

Chen Qian, Wang Rui, Fang Xiangqun and Liu Youning(Chinese PLA General Hospital, Beijing 100853)  
Bacterial biofilm (BF) induced by Pseudomonas aeruginosa was established, and was detected by a rapid method with BF stained with AgNO_3. Scanning electron microscope was used to study the morphology and structure of BF. The difference of the stained BF influenced by fleroxacin hydrochloride (FLRX) of 0, 1, 4,16×MIC was counted up by using computer image analysis with significance of P0.001. Results showed that there existed concentrationdependent relationship between the effects of FLRX controlling BF and the different concentrations. It suggested that the detail invitro experiment data provided in this report would be beneficial to clinicians in the treatment of biofilm associated infections.
【Fund】: 国家自然科学基金1997~1999资助项目
【CateGory Index】: R978.1
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