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《Cancer Research on Prevention and Treatment》 2009-08
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Apoptosis of Human Lung Cancer Line A549 Induced by Bailonglingshatang Extract

CHEN Huan-chao1,GAN Ning 1,YAO Pin-fang2,LI Jin3,LI Guang-can2,HU Zhi-ping11.Intergration of Chinese and Westerm Medicine Section,Hubei Cancer Hospital,Wuhan 430079,China;2.The Cancer Insititude of Hubei;3.South-central University For Nationalities  
Objective To observe the effect of Bailonglingshatang(BLLST) extract on apoptosis of human lung cancer cell line A549.Methods The human lung cancer cell line A549 was in vitro co-cultured with BLLST extract for 48 and 72 h,respectively.Immunocytochemical method was used to detect the expression of bcl-2 and bax.Results The expression of bcl-2 was down-regulated and the expression of bax was up-regulated in A549 cells after treated by the BLLST extract.Conclusion BLLST extract can restrain lung cancer cell multiplication,down-regulate the expression bcl-2 and up-regulate the expression bax.
【CateGory Index】: R734.2
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