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《Cancer Research on Prevention and Treatment》 2012-08
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Relationship of CD44~+/CD24~(-/low) with Responsiveness of Breast Cancer to Anthracycline-based Chemotherapy

Zhou Xin1,Wu Chengyi2 1.Department of Breast Surgery,Chongqing Cancer Institute,Chongqing 400030,China;2.Department of Endocrine and Breast Surgery,The First Affiliated Hospital,Chongqing Medical University  
Objective To evaluate the expression of CD44+/CD24-/low and the relationship between CD44+/CD24-/low and the response to anthracyclines-based chemotherapy in patients with breast cancer.Methods A total of 91 patients with breast cancer were treated with anthracycline-based neoadjuvant chemotherapy,and the clinical response to the chemotherapy was obtained after 2 to 4 cycles.Double-staining immunohistochemistry was used to detect the expression of CD44+/CD24-/low in paraffin-embedded tissues of pre-chemotherapy and post-chemotherapy.Data was analyzed via t test and Chi-square test.Results The expression rate of CD44+/CD24-/low phenotype was 39.6%(36/91).The proportions of CD44+/CD24-/lowcells were significantly increased after anthracyclines-based chemotherapy(P=0.028).The positive rate of ER in CD44+/CD24-/low positive group was lower than that in CD44+/CD24-/low negative group(25.0% vs.47.3%,P=0.033).And the expression rate of CD44+/CD24-/low phenotype in triple negative breast cancer was higher than that in non-triple negative breast cancer(61.9% vs.32.9%,P=0.017).There was no significant correlation between CD44+/CD24-/low phenotype and the other clinicopathological parameters,such as age,tumor size,TNM classification,pathological type,histological grade and so on(P0.05).The overall response of CD44+/CD24-/lowpositive group was higher but had no difference compared with CD44+/CD24-/low negative group(75% vs.69.1%,P=0.542),and the rate of pathological complete remission(pCR) in CD44+/CD24-/lowpositive group was higher than that in CD44+/CD24-/lownegative group(38.9% vs.18.2%,P=0.028).Conclusion CD44+/CD24-/lowcells are demonstrated in certain breast cancer,CD44+/CD24-/low phenotype is associated with triple negative breast cancer and the responsiveness of breast cancer to anthracycline-based chemotherapy.CD44+/CD24-/low phenotype may be used as one of the indicators to evaluate the clinical chemotherapeutic response of the patients with breast cancer.
【CateGory Index】: R737.9
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