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《CANCER RESEARCH ON PREVENTION AND TREATMENT》 1999-03
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The Effect of SRRS Prenventing P 53 Gene from Mutation

Zhao Aiguang,Yang Jinkun,Xiao Zhuoxiang,et al Department of Oncology,Longhua Hospital Affiliated of Shanghai University of Traditional Chinese Medicine and Pharmacology,Shanghai 200032  
In order to study the mechanism of the tumor suppressor effect of the “SRRS”,a recipe composed of some Chinese herbs,the mutation of P 53 gene exon 7 in the tumor tissue was observed by PCR SSCP in the nude mice Lovo transplantation tumors.The important observation of this study was that none of the samples(0/10)was shown to have P 53 gene exon7 mutation in the experimental group which SRRS was taken.After all,50%(5/10) of the samples were shown to have P 53 mutation in the control group.This result suggested that SRRS could prevent P 53 gene from mutating during the Lovo transplatstion tumors growing.
【CateGory Index】: R73-36,R735.05
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