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《Chinese Journal of Clinical Anatomy》 2012-03
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Comparison of AQP4 expression and MRI images between two kinds of ICH animal models

ZHANG Bo,SUN Shan-quan,GAN Sheng-wei,WU Xiu-yu,ZHONG Xiao-yan Institute of Neurobiology,Chongqing Medical University,Chongqing 400016,China  
Objective To compare the difference of AQP4 expression and MRI images between two kinds of ICH animal models.Methods Collagenase and autoblood were injected into the caudate nucleus to establish ICH models in rats respectively.MRI was performed at 6h,12h,1d,2d,3d and 7d for measuring the volume of hematoma.The changes of brain water content(BWC) were measured by wet and dry weight methods.Evan's blue(EB) was used to measure the integrity of BBB.The contents of AQP4 were detected by immunoblotting.Results For collagenase model,the hematoma volume and BWC reached peak at d1 and maintained until d3,while EB contents reached the peak at 12h and maintained until d2.However,the hematoma volume of autoblood model animal reached the peak at 12h,and gradually reduced at d2.EB content gradually reduced at d1.The expression of AQP4 increased at 6h and reached the peak at d1 and gradually reduced at d2 in two kinds of ICH models,which presented a significant differences in two ICH models(P0.05).Conclusions The changes of AQP4 expression and the destruction of BBB or extracellular matrix induced by collagenase maybe the reasons of the difference in hematoma volume between two ICH models.
【CateGory Index】: R743.3;R445.2
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