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《Chinese Journal of Rehabilitation》 2014-03
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A focal brain trauma model for rehabilitation study

SHEN Xia-feng;WU Jun-fa;YU Hui-xian;Department of Rehabilitation,Shanghai First Rehabilitation Hospital;  
Objective:To establish an animal experimental focal traumatic brain injury(TBI)model for investigating the underlying mechanisms of rehabilitation.Methods:After adult SD rats had received a severe controlled cortical impact(CCI)injury,they were randomly assigned to TBI group(n=8)or sham operation group(n=8).After TBI,the neurological deficits scoring,foot-fault test and cylinder test were performed.On 21-25days post-injury,rats were tested for spatial learning and memory in a Morris Water Maze.On 28days post-injury,animals were sacrificed and evaluated for quantitative cortical lesion volume and pathological changes.Results:The rats in TBI group demonstrated declined neurological deficits scores,coordination and asymmetry compared to sham operation group(P0.05).The rats in TBI group showed obvious deficits in spatial learning and memory(P0.05).We also observed significant change in lesion volume,neuron loss and overexpression of microglia around the lesion in TBI group(P0.05).Conclusion:Rats undergoing a severe CCI injury showed significant sensorimotor,cognitive performance impairment and pathological changes.It is suggest that the model should be useful for assessing the effects of rehabilitation in TBI.
【CateGory Index】: R651.1;R-332
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