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《Chinese Journal of Multiple Organ Diseases in the Elderly》 2003-01
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Effect of RAS on left ventricular function after myocardialischemia and reperfusion in anesthetized rats

PENG Hui,HUANG JieyingDepartment of Cardiology,Beijing Friendship Hospital,Beijing 100050,China  
Objective To investigate the effect of RAS on left ventricular function after myocardial ischemia and reperfusion in rats, and the effects of losartan and perindopril. Methods The Sprague Dawley rats were randomly assigned to one of the following treatment groups: ① sham operated group (S); ② control group (C); ③ losartan treated group (L); ④ perindopril treated group (P). Infarction was produced by left coronary artery ligation. Following 30 min of occlusion, reperfusion of the ischemic area for 60 min was allowed. The suture thread was applied but not tied in sham operated group. During ischemia and reperfusion periods, heart rate (HR), mean blood pressure (MAP), heart rate pressure product (RPP), left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP) and ±dp/dt were measured. Plasma level of angiotensin(Ang)Ⅰ, AngⅡ, plasma renin activity(PRA),aldosterone(Ald) and the plasma concentration of CK and NE were measured. Results ① The LVEDP was higher in C and drug treatment groups than in S one, moreover, with the value of LVEDP highest in C group. The ±dp/dt was significantly reduced in C and treatment groups, with the value in C group being lowest(P0.05). ② After drug administration, the MAP and RPP were significantly lower in L and P groups than in S and C ones (P0.05).③ Comparing with S group, the plasma concentration of CK and NE were increased in C group. The plasma CK and NE levels were lower in L and P groups than in C group (P0.05). ④ Comparing with S group, the plasma levels of AngⅠ, AngⅡ, PRA and Ald were higher in C group (P0.05). Conclusions ① After myocardial ischemia and reperfusion, left ventricular dysfunction occurred. ② The circulating RAS was activated after ischemia and reperfusion. ③ Losartan and perindopril could restrict the necrosis of myocardium, inhibit the release of catecholamine, and improve left ventricular function.
【CateGory Index】: R54
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