Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Multiple Organ Diseases in the Elderly》 2003-01
Add to Favorite Get Latest Update

Effect of RAS on left ventricular function after myocardialischemia and reperfusion in anesthetized rats

PENG Hui,HUANG JieyingDepartment of Cardiology,Beijing Friendship Hospital,Beijing 100050,China  
Objective To investigate the effect of RAS on left ventricular function after myocardial ischemia and reperfusion in rats, and the effects of losartan and perindopril. Methods The Sprague Dawley rats were randomly assigned to one of the following treatment groups: ① sham operated group (S); ② control group (C); ③ losartan treated group (L); ④ perindopril treated group (P). Infarction was produced by left coronary artery ligation. Following 30 min of occlusion, reperfusion of the ischemic area for 60 min was allowed. The suture thread was applied but not tied in sham operated group. During ischemia and reperfusion periods, heart rate (HR), mean blood pressure (MAP), heart rate pressure product (RPP), left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP) and ±dp/dt were measured. Plasma level of angiotensin(Ang)Ⅰ, AngⅡ, plasma renin activity(PRA),aldosterone(Ald) and the plasma concentration of CK and NE were measured. Results ① The LVEDP was higher in C and drug treatment groups than in S one, moreover, with the value of LVEDP highest in C group. The ±dp/dt was significantly reduced in C and treatment groups, with the value in C group being lowest(P0.05). ② After drug administration, the MAP and RPP were significantly lower in L and P groups than in S and C ones (P0.05).③ Comparing with S group, the plasma concentration of CK and NE were increased in C group. The plasma CK and NE levels were lower in L and P groups than in C group (P0.05). ④ Comparing with S group, the plasma levels of AngⅠ, AngⅡ, PRA and Ald were higher in C group (P0.05). Conclusions ① After myocardial ischemia and reperfusion, left ventricular dysfunction occurred. ② The circulating RAS was activated after ischemia and reperfusion. ③ Losartan and perindopril could restrict the necrosis of myocardium, inhibit the release of catecholamine, and improve left ventricular function.
【CateGory Index】: R54
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 GAO Ling, WANG Yan-lin, WANG Cheng- yao , et al. Department of Anesthesia, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;Effect of losartan on myocardial ischemia-reperfusion induced activation of NF-κB in rats[J];Chinese Journal of Anesthesiology;2006-02
Chinese Journal Full-text Database 10 Hits
1 Yu Xiaoling,Liu Feng,Shi Zengli, et al (Department of Pathophysiology,Binzhou Medical College,Binzhou 256603);CHANGES OF IL-6 AND TNF-α CONTENTS WITH TIME DURING RENAL ISCHEMIA/REPERFUSION IN RATS[J];Journal of Binzhou Medical College;2002-01
2 W ANG Ling and HUA Ji-De Department of General Surgery , Xijing Hospital Department ofGeneral Surgery, Changhai Hospital , Shanghai;Study on the cell injury of multiple organs in hemorrhagic shock andreperfused rats[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1994-06
3 Jia Qinhui 1, Jia Guoliang 1, Chen Shiliang 1, Li Xiaoye 3, Chen Min 2, Cao Yunxin 4 1Department of Cardiovasology, 2Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710033 3Department of Chemistr;Changes of myocardial renin activity, the content of angiotensin Ⅱ and norepinephrine in the brief postischemic reperfused myocardium in the rabbit[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1996-05
4 YANG Jin-cheng, JI Xi-qing, LI Chao-long, LIN Jian-hua, LIU Xing-guoDepartment of Hepatobiliary and Vascular Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.;Impact of early-stage hepatic ischemia-reperfusion injury on other organs of rats[J];Journal of First Military Medical University;2004-09
5 ZHAN Chengye,PAN Lili,LIU Nian,et al. Department of Emergency Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030, China;Expression of myocardial intercellular adhesion molecule-1 during hypertensive left ventricular hypertrophy[J];Journal of Emergency Medicine;2005-01
6 SHENG Xi lin, WANG Dong ming, CHEN CHang,ZHANG Xi hua, XU Duan min, YUAN Wen jin, SHI Yong ying(Department of Cardiovascular,the First Affiliated Hospital of Shantou University,Shantou 515041,China);Changes of Interleukin-10 and MPO,CK-MB During Myocardial Ischemia and Reperfusion in Rats[J];Acta Academiae Medicinae Jiangxi;2003-03
7 WANG Fei, GAO Xiao-feng ,LIN Zi-bo (Huizhou City Central People's Hospital, Huizhou, Guangdong 516000,Chin a );Effects of nitric oxide on apoptosis of liver ischemia-reperf usion damage in rats[J];Heilongjiang Medicine and Pharmacy;2005-02
8 WU Hong,LANG Xi long,MA Li ping,et al (Changhai Hospital,the Second Military Medical University,Shanghai 200433,China);Effect of anti-ICAM-1 monoclonal antibody on cardiac function in rats with early or long term reperfusion after myocardial ischemia[J];Editorial Department of Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Disease;2003-02
9 WANG Hong mei 1 XU Jiang tao 2 ZHANG Jian long 1 BIAN Wen an 3 1Department of Pathophysiology, The College of Pre clinical Medicine, Xinjiang Medical University(Wulumuqi 830054,China) 2Department of Neurology,PLA General Hospital of Lanzhou Military Command(Wu lumuqi 830000,China) 3Department of Clinical Laboratory ,Cancer Hospital, Xinjiang Medical University(Wulumuqi 830054,China);The expression of NF-κB and ICAM-1 in brain of rats during the period of liver ischemia reperfusion injury[J];Chinese Journal of Current Advances in General Surgery;2005-01
10 ZHU Xiao qing 1,LEI Shui sheng 1,HU Qi sheng 2 (1 Xianning Medical College,Xianning 437100,China; 2 Medical College of Wuhan University,Wuhan 430071,China);Protective effect and mechanism of tetramethylpyrazine on small intestinal ischemia reperfusion injury in rats[J];Shandong Journal of Traditional Chinese Medcine;2002-08
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 LUO Gang-jian,GAN Xiao-liang,SHEN Ning,HEI Zi-qing,LI Shang-rong,CHEN Li-xin Department of Anesthesiology,Third Affiliated Hospital,SUN Yat-sen University,Guangzhou 510630,China;Cromolyn sodium ameliorates rat left cardiac function during intestinal ischemia-reperfusion[J];Journal of Southern Medical University;2007-05
2 Yao Shutong, Li Yuzhen, Liu Xiuhua, et al/Department of Pathophysiology, PLA General Hospital, Beijing 100853;Effect of Ischemic Postconditioning on Mesenteric Microcirculation of Rats Subjected to Small Intestinal Ischemia/Reperfusion Injury[J];Chinese Journal of Microcirculation;2007-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved