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《Chinese Journal of Multiple Organ Diseases in the Elderly》 2010-04
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Relationship of methylation of p16 gene with long life expectancy of Zhuang ethnic group elderly people:report of 156 cases in Guangxi Bama area

CHEN Wencheng,PAN Shangling,QIN Zhijian,et al Department of Clinical Microbiology and Immunology,Medical Laboratory College,Youjiang Medical College for Nationalities.Baise 533000,China  
ObjectiveTo explore the relationship between the methylation of p16 gene and human longevity.MethodsThe methylation specific polymerase chain reaction was used to analyze the methylation status of p16 gene in 156 long-lived healthy Zhuang ethnic group people (aged 90-105 years,mean 93.2 years,long-lived group,LG) and 142 healthy controls (aged 20-72 years,mean 34.8 years,control group,CG) from Bama area. The difference in p16 gene methylation between the two groups was analyzed to study the role of p16 gene methylation in human longevity. ResultsThe methylation of p16 gene was more frequent in CG than in LG. ConclusionThe methylation of p16 gene is less frequent in long-lived Zhuang ethnic group elderly people in Bama area.
【Fund】: 广西科学基金(桂科自0728160);; 广西教育厅基金(No.右科配JYT0702006)
【CateGory Index】: R394
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Liu Xiaoyin, Wang Huiyuan, Lu Yunxia et al (Anhui Medical University, Hefei 230032);Establishment and preliminary application of methylation-specific method for detecting p16 gene[J];Acta Universitis Medicinalis Nahui;2002-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHAO Yingshe,ZHANG Sizhong *.*Department of Medical Genetics, The Affiliated Hospital, West China University of Medical Sciences, Chengdu, 610041 P.R.China.E mail:zszg@wcums.edu.cn;Detection of methylation status of tumor suppressor gene p16 by methylation specific polymerase chain reaction[J];CHINESE JOURNAL OF MEDICAL GENETICS;1999-05
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