The Effects of Ge401 on the Learning Ability and Memory of Spatial Dizerimination and on the M-cholinoceptor Regulation in Cerebral Cortex-hlppocampus of the Aged Mice
Wang Xincheng, et al Department of Physiology Shanghai Worker and Staff Medial College Shanghai 200020
Using Tri-arm Y-maze (DS-lype) method, the learning ability and memory of spatial discrimination was studied on aged mice treated with Ge401, Immediately after the Y-maze experiment the animals were decapitated and the cerebral eortexhippocampus were homogenized and 3H-QNB radioligant saturation biniding assay were performed. The results showed that Ge101 could improve the learning ability and memory as compared with control group, and the amount of Mcholiuoceptor of Ge401 group were about 70% highdr than that of control group (P00.01). It is suggested that Ge401 possesses up-regulation aotion to M-cholinoceptor, and the improvement of learning ability and memory in older mioe may be attributede by this aotion.