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Neuron adhesion mechanism in substantia nigra compacta of Parkinson's disease mice by electroacupuncture therapy correlated to dopaminergic neural plasticity

TANG Yong, YU Shu-Guang,CHEN Jin. Lab of Chronobiology, Acupuncture & Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China  
Objective To explore the effect of neural cell adhesion molecule(NCAM)on dopaminergic plasticity of substantia nigra compacta (SNC) in Parkinson's disease (PD) mice enhanced by electroacupuncture (EA). Methods PD model mice induced by 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine were as subjects. Hegu and Taichong were punctured once daily, 7 times as one period. The expressions of NCAM and NCAM mRNA were determined by immunohistochemistry and in situ hybridization after three periods. Results The NCAM(92.67±2.52)and NCAM mRNA(230.33±17.16)positive cells in EA group were higher than those(54.00±10.39, 138.33±5.86)in model group (P0.05, P0.01).Conclusions EA could promote the expression of NCAM and NCAM mRNA in PD mice SNC and enhance degenerative dopaminergic neuron plasticity.
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