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《Chinese Journal of Gerontology》 2005-04
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The content changes of SOD and MDA in important organic tissues of adult diabetic rat

LI Xiao-Lin, LI Xiao-Mei, LU Yan-Juan, et al . Experimental Center for Biochemistry and Molecular Biology, Basic Medical College of Jilin University, Changchun 130021, Jilin, China  
Objective To investigate the content changes of SOD and MDA in important organic tissues of adult diabetic rat. Methods SOD activity and MDA content in rats'tissues among control (C) group, diabetic (D) group and insulin therapy (ID) group were determined. Results SOD activity of D group significantly decreased in heart, liver, lung, spleen and pancreas comparing to that of C group (P~0.01 , P0.05), that of ID group significantly decreased in liver, spleen and pancreas comparing to that of C group (P0.05), that of D group significantly increased in lung (P0.05), but had no changes in kidney comparing to that of ID group. MDA content of D group significantly increased in heart, lung, pancreas and spleen comparing to that of C group (P0.05, P0.01); there were significant differences in MDA content in heart, pancreas and spleen between ID group and C group (P0.05, P0.01), and in heart and spleen between ID group and D group (P0.05, P0.01); there were no changes in MDA content in liver and kidney among three groups. Conclusions The low level of antioxidase in important organic tissues of diabetic rat should have tendency to increase by insulin therapy.
【Fund】: 国家自然科学基金资助项目(39870313)
【CateGory Index】: R587.105
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